Evidence map›Paper›PMID 41136682›Full record

ArticleNpj imaging2025

Oral intake of deuterated choline at clinical dose for metabolic imaging of brain tumors.

Victor E Osoliniec, Monique A Thomas, Robin A de Graaf, Henk M De Feyter

Abstract read
In one paragraph

Article in Npj imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Victor E OsoliniecMagnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Monique A ThomasMagnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Robin A de GraafMagnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Henk M De FeyterMagnetic Resonance Research Center, Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA. henk.defeyter@yale.edu.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI MEGAN C KING · 1985 to 2026
$85.0M
Deuterium metabolic imaging (DMI) of neurological diseaseR01EB025840 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2019 to 2026
$4.2M
Validation of imaging brain tumor metabolism using deuterated glucoseR01EB033764 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2023 to 2026
$2.4M
Single-scan, multi-contrast imaging of glucose metabolism in patients with glioblastomaR01CA288833 · NCI · YALE UNIVERSITY · PI Henk De Feyter · 2025 to 2026
$1.4M
Mapping of choline uptake and metabolism in brain tumors with deuterium metabolic imaging (DMI)R03CA267438 · NCI · YALE UNIVERSITY · PI DE FEYTER, HENK · 2023 to 2024
$168k
NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA288833NCI NIH HHS R03 CA267438NIBIB NIH HHS R01 EB025840NIBIB NIH HHS R01 EB033764NIH HHS R01EB033764
6 · The paper itself

Abstract

Deuterium metabolic imaging (DMI) is a new imaging approach that provides unique, complementary information to anatomical MRI of brain tumors. Preclinical DMI studies have demonstrated excellent image contrast following intravenous infusion of deuterated choline (

Identifiers

PMID41136682
PMCPMC12552732

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.