ArticleJournal of computer-aided molecular design2025
Synthesis, characterization, docking, MD simulation, and evaluation of antiproliferative effectiveness of new 4-aminobenzophenone derivatives.
Article in Journal of computer-aided molecular design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Quantum mechanical and molecular dynamics insights into the binding mechanism of tubulin-stabilizing agents at the taxol site of β-tubulin.Journal of molecular modeling · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A series of six new compounds (1-6) were synthesized through the implementation of chemical reactions, employing the starting material 4-aminobenzophenone and six distinct aldehyde derivatives. The antiproliferative activities of the compounds 1-6 were evaluated to assess their potential as anticancer agents. Considering that structurally similar compounds have been reported as tubulin polymerization inhibitors, in silico studies were conducted to investigate the binding interactions of the synthesized derivatives with the colchicine-binding site of tubulin. Molecular docking studies indicated favorable binding affinities for all compounds toward the target site. Furthermore, molecular dynamics (MD) simulations confirmed the stability of the ligand-tubulin complexes, supporting the potential of these 4-aminobenzophenone derivatives as candidate tubulin-targeting anticancer agents.
Indexed as
Identifiers
41136679What OpenQuestion holds
Registered trials
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