Evidence map›Paper›PMID 41136672›Full record

Observational studyNeurocritical care2026

Hematocrit-to-Hemoglobin Ratio as a Novel Independent Predictor for In-Hospital Mortality and Delayed Cerebral Ischemia in Critically Ill Patients with Aneurysmal Subarachnoid Hemorrhage Requiring Neurosurgical or Endovascular Treatment: A Retrospective Analysis.

Emanuel Moisa, Georgeana Tuculeanu, Liliana Mirea, Claudia Mihail, Stefanita Dima, Liviu Ioan Serban, Dan Corneci, Federico Bilotta, Silvius Ioan Negoita

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Brain-kidney crosstalk in subarachnoid hemorrhage patients.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emanuel MoisaDepartment of Anesthesiology and Critical Care, Carol Davila University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, 020021, Bucharest, Romania. emanuel.moisa@umfcd.ro.ORCID http://orcid.org/0000-0001-8138-8622
Georgeana TuculeanuDepartment of Anesthesiology and Critical Care, Carol Davila University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, 020021, Bucharest, Romania.
Liliana MireaDepartment of Anesthesiology and Critical Care, Carol Davila University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, 020021, Bucharest, Romania.
Claudia MihailDepartment of Anesthesiology and Critical Care, Elias Emergency University Hospital of Bucharest, Mărăsti Blvd., No. 17, 011461, Bucharest, Romania.
Stefanita DimaDepartment of Interventional Radiology, Elias Emergency University Hospital of Bucharest, Mărăsti Blvd., No. 17, 011461, Bucharest, Romania.
Liviu Ioan SerbanDepartment of Anesthesiology and Critical Care, Elias Emergency University Hospital of Bucharest, Mărăsti Blvd., No. 17, 011461, Bucharest, Romania.
Dan CorneciDepartment of Anesthesiology and Critical Care, Carol Davila University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, 020021, Bucharest, Romania.
Federico BilottaDepartment of Anesthesiology and Critical Care, University Tor Vergata of Rome, Via Cracovia, 50, 00133, Rome, Italy.
Silvius Ioan NegoitaDepartment of Anesthesiology and Critical Care, Carol Davila University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, 020021, Bucharest, Romania.

Funding

Universitatea de Medicină şi Farmacie "Carol Davila" Bucureşti Publish not Perish
6 · The paper itself

Abstract

backgroundSubstantial research has been dedicated to new prognostication tools in aneurysmal subarachnoid hemorrhage (aSAH), with a recent focus on laboratory parameters. Our study investigates the predictive value of a new hematological index, the hematocrit-to-hemoglobin (Ht-to-Hb) ratio, for mortality and delayed cerebral ischemia (DCI).

methodsThis is a retrospective, single-center, observational study on 78 adult critically ill patients with aSAH. We collected data from the electronic and written records, including demographic and clinical data, therapeutic measures, and intensive care unit and hospital length of stay. The primary outcome was in-hospital mortality, whereas the secondary outcome was DCI development. After descriptive analysis was performed, the Ht-to-Hb ratio was tested as a predictor for the primary and secondary outcomes. Firstly, we conducted a receiver operating characteristic analysis, and cutoff values were identified using the Youden index. Further, in-hospital mortality and DCI probability were evaluated using the log rank test. Cox proportional hazards regression was conducted to test the independent predictive value of the Ht-to-Hb ratio for the aforementioned outcomes.

resultsMortality during hospitalization was 25.54%, whereas DCI frequency was 42.3%. The Ht-to-Hb ratio had areas under the receiver operating characteristic curve for death prediction and DCI of 0.85 and 0.734, respectively. Values greater than the cutoff value for mortality, 3.069, were independently associated with the primary outcome in the multivariable analysis (hazard ratio [HR] 4.64, 95% confidence interval [CI] 1.08-19.98, p = 0.039). For DCI, the cutoff value identified was 3.007. Ht-to-Hb ratios > 3.007 were an independent risk factor for DCI in the multivariable analysis (HR 3.86, 95% CI 1.43-10.4, p = 0.008).

conclusionsThe present study proposes a new prognostic index for mortality and DCI in aSAH: the Ht-to-Hb ratio. This marker could act as a surrogate for blood viscosity, uncovering the importance of blood rheology in aSAH pathogenesis.

Indexed as

Brain IschemiaHemoglobinsHospital MortalitySubarachnoid HemorrhageAdultAgedCritical IllnessEndovascular ProceduresFemaleHematocritHumansMaleMiddle AgedNeurosurgical ProceduresPredictive Value of TestsPrognosisHemoglobinsAneurysmal subarachnoid hemorrhageBlood viscosityDelayed cerebral ischemiaHematocrit-to-hemoglobin ratioICURheology

Identifiers

PMID41136672
PMCPMC13053589

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.