Evidence map›Paper›PMID 41136662›Full record

ArticleScientific reports2025

Mean platelet volume as a biomarker of anemia and platelet disorders among metabolic syndrome patients in Northwest Ethiopia.

Amanuel Kelem, Getabalew Engidaye, Befikad Mandefro, Mickael Workineh Alemu, Bedasa Addisu, Zewudu Mulatie, Bisrat Birke Teketelew, Mesay Arkew, Tiruneh Adane

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Amanuel KelemDepartment of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia. amanuelkelem@gmail.com.
Getabalew EngidayeDepartment of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.
Befikad MandefroDepartment of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.
Mickael Workineh AlemuDepartment of Medical Laboratory Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia.
Bedasa AddisuDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia.
Zewudu MulatieDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Bisrat Birke TeketelewDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Mesay ArkewSchool of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Tiruneh AdaneDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic syndrome (MetS) is associated with increased cardiovascular risk, and platelets play a significant role in its pathophysiology. Mean platelet volume (MPV) is a marker of platelet activity. This study investigates the relationship between MPV and hematological abnormalities in MetS patients in Northwest Ethiopia. A cross-sectional study was conducted on adult MetS patients at the University of Gondar Comprehensive Specialized Hospital. Data on hematological parameters, anthropometric measurements, and biochemical profiles were collected using standard procedures. Six milliliters of venous blood were taken to conduct hematological and biochemical analyses, using an automated hematology and chemistry analyzer, respectively. Spearman's rank correlation and Mann-Whitney U tests were used to analyze associations between MPV and other variables. Statistical significance was determined at P-value < 0.05. Weak positive correlations were found between MPV and RBC count (ρ = 0.1588, P = 0.0018), Hgb level (ρ = 0.1621, P = 0.0014), and Hct (ρ = 0.2119, P < 0.0001), while a moderate negative correlation was observed between MPV and platelet count (ρ = -0.3988, P < 0.0001). MetS patients with anemia exhibited significantly lower median MPV values, while those with thrombocytopenia showed significantly higher median MPV values. Conversely, patients with thrombocytosis had significantly lower median MPV values compared to those without thrombocytosis. MPV is associated with hematological abnormalities in MetS patients in Northwest Ethiopia. Lower MPV was found in anemic MetS patients, while higher MPV was linked to thrombocytopenia, suggesting MPV's potential as a marker for assessing platelet dysfunction in MetS.

Indexed as

AnemiaBlood Platelet DisordersMean Platelet VolumeMetabolic SyndromeAdultBiomarkersBlood PlateletsCross-Sectional StudiesEthiopiaFemaleHumansMaleMiddle AgedPlatelet CountBiomarkersAnemiaMean platelet volumeNorthwest EthiopiaPlatelet disorder

Identifiers

PMID41136662
PMCPMC12552486

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