Evidence map›Paper›PMID 41136571›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Comparison between intralesional steroid injection vs. blue laser therapy for Reinke's edema in an office setting: a case study.

Abdul-Latif Hamdan, Lana Ghzayel, Zeina Maria Semaan, Jonathan Abou Chaar, Omar Aboul Hosn, Ibana Carapiperis, Patrick Abou Raji Feghali

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Abdul-Latif HamdanDepartment of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon. ah77@aub.edu.lb.ORCID http://orcid.org/0000-0003-1493-3568
Lana GhzayelDepartment of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon.
Zeina Maria SemaanDepartment of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon.
Jonathan Abou ChaarDepartment of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon.
Omar Aboul HosnDepartment of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon.
Ibana CarapiperisDepartment of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon.
Patrick Abou Raji FeghaliDepartment of Otolaryngology - Head and Neck Surgery, American University of Beirut Medical Center, 11-0236, Riad El Solh, Beirut, 1107 2020, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study is to compare office-based laser therapy (OBLT) to intralesional steroid injections (ILSI) in the treatment of Reinke's edema (RE).

methodsThe medical records and video-recordings of patients diagnosed with RE who underwent office-based therapy at the Voice and Swallowing Unit between November 2022 and December 2024 were reviewed. The primary outcome measures used were disease regression and patient-reported improvement in voice quality. Secondary outcome measures included acoustic voice parameters.

resultsA total of 19 patients were included in the study, with a mean age of 55 ± 13.28 years. Two patients had unilateral disease while 17 had bilateral disease (total of 36 lesions). Seventeen lesions were rated as type 1, two as type 2 and fourteen as type 3. Partial disease regression was noted in 24 lesions (66.7%) and complete disease regression was noted in 12 lesions (33.3%). There was no statistically significant difference in partial or complete disease regression between OBLT and ILSI (p = 0.414 and p = 0.248, respectively). There was no statistically significant difference in the drop of mean VHI-10 scores between the two groups (p = 0.252). There was also no significant difference in the change in any of the acoustic parameters.

conclusionOBLT and ILSI are effective in treating RE. There was no significant difference in any of the outcome measures between the two approaches. A larger sample size is needed to establish if there are disease-related differences, such as type of RE using either treatment modality.

Indexed as

GlucocorticoidsLaryngeal EdemaLasers, DyeLaser TherapyAdultAgedFemaleHumansInjections, IntralesionalMaleMiddle AgedRetrospective StudiesTreatment OutcomeVocal CordsVoice QualityGlucocorticoidsBlue laserIntralesional steroids injectionLaryngologyOffice-basedReinke’s edema

Identifiers

PMID41136571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.