ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Prognostic value of systemic inflammatory markers in head and neck squamous cell carcinoma.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to estimate the prognostic value of the inflammatory indexes (NLR, PLR, LMR, SII, and SIM) in the prognosis of patients with HNSCC.
methodsWe retrospectively studied 396 patients with HNSCC diagnosed and managed over the last decade in the First Otolaryngology department of Hippokrateion hospital. The inflammatory marker counts were obtained from the pre-operative blood tests, and the survival data were recorded through the patients' follow-up. The Kaplan-Meier method, the Cox proportional hazards model, and the receiver operating characteristics (ROC) curve were used to determine the prognostic values of the inflammatory markers and other factors.
resultsFactors found to be significantly associated with both DFS and OS were higher body mass index (BMI), tumor location, cancer stage (patients with advanced cancer stage reported lower DFS and OS), primary treatment, ECOGI PS scale and Charlson Index. Inflammatory marker PLR was found to be a significant predictor in both DFS (HR = 1.329; 95% CI = 1.041, 1.697) and OS (HR = 1.398; 95% CI = 1.073, 1.823), indicating that patients with higher PLR (cut off equal to 155) have a higher hazard of death. The same findings were present for SII regarding DFS (HR = 1.280; 95%CI = 1.013, 1.618), whereas the HR regarding OS was borderline but non-significant (HR = 1.168; 95%CI = 0.895, 1.525).
conclusionPlatelet-based inflammation markers were qualified as novel and independent prognostic factors, and they could be useful biomarkers for predicting survival outcomes in patients with HNSCC.
Indexed as
Identifiers
41136566What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.