Evidence map›Paper›PMID 41136562›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Injection laryngoplasty versus medialization thyroplasty for unilateral vocal cord paralysis: a comprehensive systematic review and meta-analysis.

Mohammed H Baali, Manal A Bukhari, Mohammed I Almohizea, Sara A Almansour, Mohammad H Shaheen, Shrooq H Alswat

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammed H BaaliLaryngology and phonosurgery fellow, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia. mohammedbaali@hotmail.com.ORCID http://orcid.org/0009-0007-6730-3646
Manal A BukhariLaryngology and phonosurgery fellow, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohammed I AlmohizeaLaryngology and phonosurgery fellow, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Sara A AlmansourLaryngology and phonosurgery fellow, Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohammad H ShaheenDepartment of Otolaryngology-Head and Neck Surgery, Hera General Hospital, Makkah, Saudi Arabia.
Shrooq H AlswatDepartment of Otolaryngology-Head and Neck Surgery, Alhada Armed Forces Hospital, Taif, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUnilateral vocal cord paralysis (UVCP) is a debilitating disorder that affects patients' vocalization and swallowing. Medialization thyroplasty (MT) and injection laryngoplasty (IL) are the most widely used surgical procedures for treating UVCP. This is the first direct meta-analysis on the effectiveness of IL in treating UVCP in comparison with MT.

methodsOn the 15th of December, 2024, a systematic search was conducted in biomedical databases. Search results were gathered and screened for relevant primary studies. Data were extracted, and inverse variance meta-analysis was conducted whenever applicable using the RevMan software. The results were pooled as mean difference (MD) or standardized MD, each reported with its corresponding 95% confidence interval. Statistical significance was determined when the P-value was under 0.05.

resultsThirteen studies that enrolled 896 patients were included (428 underwent IL while 444 underwent MT). A trend towards short- and long-term improvements was noticed in voice jitter with IL (short-term: MD=-0.59, 95% CI: [-1.03, -0.14], P = 0.01; long-term: MD=-0.70, 95% CI: [-1.00, -0.41], P < 0.001) and in voice shimmer with MT (short-term: MD=-2.06, P = 0.003; long-term: MD=-2.51, P = 0.003), likely of the variation in each procedure's mechanics. Both IL and MT resulted in comparable improvements in the harmonic-to-noise ratio (P = 0.3), the maximum phonation time (P = 0.8), and the voice handicap index (P = 0.6) within six months post-operatively.

conclusionWe conclude comparable improvements in UVCP with both IL and MT. Further long-term studies that investigate this comparison on a large scale are required to provide case-specific conclusions.

Indexed as

LaryngoplastyVocal Cord ParalysisHumansInjectionsTreatment OutcomeVoice QualityInjection laryngoplastyMedialization thyroplastyMeta-analysisSystematic reviewUnilateral vocal cord paralysis

Identifiers

PMID41136562

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.