Evidence map›Paper›PMID 41136561›Full record

ArticleScientific reports2025

Autoimmune reactions to ACE2 triggered by SARS-CoV-2 S protein and their histopathological consequences.

Liubov Beduleva, Kseniya Fomina, Tatyana Khramova, Alexey Terentiev, Daria Menshikova, Oksana Terentieva, Igor Menshikov, Alexandr Sidorov, Polina Makhankova, Nadezhda Abisheva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liubov BedulevaLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation. lvbeduleva@gmail.com.
Kseniya FominaLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Tatyana KhramovaLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Alexey TerentievLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Daria MenshikovaLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Oksana TerentievaLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Igor MenshikovLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Alexandr SidorovLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Polina MakhankovaLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.
Nadezhda AbishevaLaboratory of Molecular and Cell Immunology, Department of Immunology and Cell Biology, Udmurt State University, 1 Universitetskaya St, Izhevsk, 426034, Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 has been shown to induce autoimmunity. Due to the idiotype-antiidiotypic interactions between lymphocytes to SARS-CoV-2 S protein and lymphocytes to angiotensin converting enzyme 2 (ACE2), the immune response to S protein can cause induction of anti-ACE2 lymphocytes. The ubiquity of ACE2 within the human body endows autoimmune reactions to ACE2 with the role of the main factor causing injuries of various tissues. Immunization of Wistar rats with S protein caused hyperplasia and dedifferentiation of type II pneumocytes, extensive injury of the proximal tubules, infiltration of CD4

Indexed as

Angiotensin-Converting Enzyme 2AutoimmunityCOVID-19SARS-CoV-2Spike Glycoprotein, CoronavirusAlveolar Epithelial CellsAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHumansKidney Tubules, ProximalLungMaleRatsRats, WistarACE2 protein, humanAce2 protein, ratAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Angiotensin converting enzyme 2AutoimmunityProximal tubulesType II pneumocyte hyperplasia

Identifiers

PMID41136561
PMCPMC12552698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.