Evidence map›Paper›PMID 41136477›Full record

ArticleScientific reports2025

Metabolic and alcohol-related steatotic liver disease and gastrointestinal cancer risk in diabetes.

Seung-Gyun Im, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Jinju Choi, Hyemin Jo, Ho-Kyoung Lee, Eun Hyo Jin, Seung Joo Kang, Joo Hyun Lim and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structural Characterisation ofMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seung-Gyun ImDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam, 13620, Gyeonggi-do, South Korea.
Cheol Min ShinDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam, 13620, Gyeonggi-do, South Korea. scm6md@gmail.com.ORCID http://orcid.org/0000-0003-2265-9845
Kyungdo HanDepartment of Statistics and Actuarial Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, Seoul, 06978, South Korea. hkd917@naver.com.ORCID http://orcid.org/0000-0002-6096-1263
Jin Hyung JungBiostatistics, The Catholic University of Korea, Seoul, South Korea.
Jinju ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam, 13620, Gyeonggi-do, South Korea.
Hyemin JoDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam, 13620, Gyeonggi-do, South Korea.
Ho-Kyoung LeeDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam, 13620, Gyeonggi-do, South Korea.
Eun Hyo JinDepartment of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.
Seung Joo KangDepartment of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.
Joo Hyun LimDepartment of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.
Yoon Jin ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam, 13620, Gyeonggi-do, South Korea.
Dong Ho LeeDepartment of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Seongnam, 13620, Gyeonggi-do, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the relationship between incidence of gastrointestinal tract cancers, metabolic dysfunction-associated steatotic liver disease (MASLD), and alcohol-related steatotic liver disease in diabetic population. A nationwide cohort of 2,616,828 individuals with diabetes under Korean National Health Insurance Service from 2015 to 2016 was divided into four subgroups: no steatosis (group 1), MASLD alone (group 2), MASLD with heavy alcohol intake (group 3), and alcoholic liver disease (group 4). We used fatty liver index to assess the probability of hepatic steatosis using cutoff scores of 30 and 60. We analyzed incidences of esophageal, stomach, colorectal, biliary, and pancreatic cancers until 2022. Compared with group 1 (reference), group 2 showed increased hazard ratios for stomach, colorectal, and biliary cancers, with a decreased hazard ratio for esophageal cancer (adjusted hazard ratio [95% confidence interval]: 1.10 [1.06-1.13], 1.13 [1.10-1.16], 1.10 [1.05-1.16], 0.88 [0.79-0.97], respectively). Probability of hepatic steatosis was positively correlated with all gastrointestinal tract cancers except esophageal cancer in non-drinkers, but only with stomach, colorectal, and biliary cancers in mild drinkers (p

Indexed as

Diabetes MellitusFatty LiverFatty Liver, AlcoholicGastrointestinal NeoplasmsAdultAgedAlcohol DrinkingFemaleHumansIncidenceMaleMiddle AgedRepublic of KoreaRisk FactorsAlimentary tractDiabetesGastrointestinal tract cancerHepatic steatosisMetabolic dysfunction-associated steatotic liver disease

Identifiers

PMID41136477
PMCPMC12552685

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.