Evidence map›Paper›PMID 41136417›Full record

ArticleNature communications2025

Explore brain-inspired machine intelligence for connecting dots on graphs through holographic blueprint of oscillatory synchronization.

Tingting Dan, Jiaqi Ding, Guorong Wu

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Variational Mean-Field Control Framework for Graph Representation Learning.IEEE transactions on pattern analysis and machine intelligence · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tingting Dan *Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6936-2649
Jiaqi Ding *Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Guorong WuDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. grwu@med.unc.edu.ORCID http://orcid.org/0000-0002-0550-6145

Funding

Understanding Selectivity Mechanisms of Network Vulnerability and Resilience in Alzheimer's Disease by Establishing a Neurobiological Basis through Network NeuroscienceRF1AG068399 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WU, GUORONG · 2020 to 2020
$1.9M
Understanding Selectivity Mechanisms of Network Vulnerability and Resilience in Alzheimer's Disease by Establishing a Neurobiological Basis through Network NeuroscienceR01AG068399 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WU, GUORONG · 2024 to 2024
$481k
Understanding the Selective Mechanism of Tau Propagation in Alzheimer's Disease Through Multi-layer Spreading PathwaysR21AG091653 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WU, GUORONG RUDY · 2025 to 2025
$420k
Understanding Mechanism of Functional Dynamics Through An Explainable Neural Network Landscape with Geometric ControlR21AG084375 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WU, GUORONG · 2024 to 2024
$417k
NIA NIH HHS R01 AG068399NIA NIH HHS R21 AG084375NIA NIH HHS R21 AG091653NIA NIH HHS RF1 AG068399
6 · The paper itself

Abstract

Neural coupling in both neuroscience and AI emerges dynamic oscillatory patterns that encode abstract concepts. To that end, we hypothesize that a deeper understanding of the neural mechanisms that determine brain rhythms could inspire next-generation design principles for machine learning algorithms, leading to greater efficiency and robustness. Following this notion, we first model the evolving brain rhythm by the interference between spontaneously synchronized neural oscillations (termed HoloBrain). The success of modeling brain rhythms via an artificial dynamic system of coupled oscillations gives rise to the "first principle" for emerging brain-inspired machine intelligence through the common mechanism of synchronization (termed HoloGraph), enabling graph neural networks (GNNs) to move beyond conventional heat diffusion paradigms toward modeling oscillatory synchronization. Our HoloGraph not only effectively addresses the over-smoothing issue in GNNs but also manifests the potential of reasoning and solving challenging problems on graphs.

Indexed as

Artificial IntelligenceBrainHolographyAlgorithmsHumansMachine LearningModels, NeurologicalNeural Networks, Computer

Identifiers

PMID41136417
PMCPMC12552636

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.