Evidence map›Paper›PMID 41136375›Full record

ArticleCell death discovery2025

Therapeutic targeting of STING-IL6/STAT3 axis to inhibit osteoclastic niche formation and breast cancer bone metastasis.

Chen Zhao, Pengcheng Liu, Keyu Kong, Xuzhuo Chen, Junxiang Wu, Wen Wu, Xiaoqing Wang, Lei Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chen Zhao *Department of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0001-7323-8237
Pengcheng Liu *Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Keyu KongDepartment of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-5839-6074
Xuzhuo ChenDepartment of Oral Surgery, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Junxiang WuDepartment of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wujunxiang9503@163.com.
Wen WuDepartment of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 13761003720@163.com.ORCID http://orcid.org/0009-0000-4830-9419
Xiaoqing WangDepartment of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. osteoclast2006@sjtu.edu.cn.ORCID http://orcid.org/0000-0003-0051-1241
Lei WangDepartment of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wanglsjtu@163.com.ORCID http://orcid.org/0009-0000-7258-2714

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81902194
6 · The paper itself

Abstract

Despite numerous studies on tumor bone metastasis, little emphasis has been placed on the role of the formation of the osteoclastic premetastatic niche (OPN), and related genetic intervention targets are relatively scarce. Our data confirm the promoting effect of OPN formation on bone metastasis and demonstrate the existence of a vicious cycle between osteoclast differentiation and breast tumor cell proliferation through in vitro cell experiments. Moreover, we show that regulating Stimulator of Interferon Genes (STING) can break this cycle. However, both in vivo and in vitro experiments further indicate that STING intervention in OPN formation and breast tumor bone metastasis depends on IL6/STAT3, with a significant discount in the presence of IL-6 activation. In summary, these data not only highlight the important role of OPN but also emphasize STING-IL6/STAT3 as a crucial intervention target.

Identifiers

PMID41136375
PMCPMC12552607

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.