ArticleTranslational psychiatry2025
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium.
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- Suicide attempts, white matter microstructure, and cognitive function in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
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122 authors.
Laura S van VelzenOrygen, Parkville, VIC, Australia. laurasvanvelzen@gmail.com.ORCID http://orcid.org/0000-0002-6003-5227
Lejla ColicDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8809-4034
Zuriel CejaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-2392-1964
Maria R DauvermannInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-2873-8512
Luca M VillaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5091-6410
Hannah S SavageCentre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Yara J ToendersOrygen, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0002-4117-1143
Niousha DehestaniMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
Alyssa H ZhuImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Adrian I CamposQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0001-9544-3944
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Nina AlexanderDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Rosa Ayesa-ArriolaDepartment of Psychiatry. Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.ORCID http://orcid.org/0000-0003-0570-5352
Elizabeth D BallardExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5304-0127
Nerisa BanajLaboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-6317-8549
Carlotta BarkhauInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Zeynep BaşgözeDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-0306-4849
Jochen BauerClinic for Radiology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-9345-2126
Francesco BenedettiDivision of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-4949-856X
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Bianca BesteherDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.ORCID http://orcid.org/0000-0001-7989-9298
Katharina BroschDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0526-8095
Manuel Canal-RiveroInstituto de Biomedicina de Sevilla (IBiS)/HUVR/CSIC/Universidad de Sevilla. CIBERSAM (ISCIII), Seville, Spain.
Simon CervenkaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8103-6977
Romain ColleMOODS Team, INSERM 1018, CESP, Université Paris-Saclay, Faculté de Médecine Paris-Saclay, Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.ORCID http://orcid.org/0000-0002-2549-4495
Colm G ConnollyDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
Emmanuelle CorrubleMOODS Team, INSERM 1018, CESP, Université Paris-Saclay, Faculté de Médecine Paris-Saclay, Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.
Philippe CourtetDepartment of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0002-6519-8586
Baptiste Couvy-DuchesneInstitute for Molecular Bioscience, the University of Queensland, St Lucia, QLD, Australia.
Benedicto Crespo-FacorroInstituto de Biomedicina de Sevilla (IBiS)/HUVR/CSIC/Universidad de Sevilla. CIBERSAM (ISCIII), Seville, Spain.
Kathryn R CullenDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-9631-3770
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-0623-3759
Jeremy DeverdunInstitut d'Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Gui de Chauliac Hospital and University of Montpellier, Montpellier, France.
Ana M Diaz-ZuluagaCenter for Neurobehavioral Genetics,Semel Institute for Neuroscience and Behavior David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Lorielle M F DietzeDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0003-2906-9282
Jennifer W EvansExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0002-7176-5759
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7720-252X
Kira FlinkenflügelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-7738-5429
Naomi P FriedmanInstitute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-4901-808X
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-3622-3199
Nynke A GroenewoldDepartment of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-0865-8427
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tomas HajekDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0003-0281-8458
Alexander S HatoumDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-8002-7267
Marco HermesdorfInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Ian B HickieThe University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0001-8832-9895
Yoshiyuki HiranoResearch Center for Child Mental Development, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0003-3844-3061
Tiffany C HoDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Yuki IkemizuResearch Center for Child Mental Development, Chiba University, Chiba, Japan.ORCID http://orcid.org/0009-0009-0276-7014
Frank IorfinoThe University of Sydney, Sydney, Australia.
Jonathan C IpserDepartment of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Yuko IsobeResearch Center for Child Mental Development, Chiba University, Chiba, Japan.ORCID http://orcid.org/0009-0004-2811-6977
Andrea P JackowskiØstfold University College Department of Education, ICT and Learning, Halden, Norway.ORCID http://orcid.org/0000-0001-8842-5406
Fabrice JollantFaculty of Medicine, University Paris-Saclay, Le Kremlin-Bicetre, France.ORCID http://orcid.org/0000-0001-5809-4503
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-2514-2625
Melissa KlugInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Sheri-Michelle KoopowitzDepartment of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Anna KrausInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-2627-4563
Axel KrugDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0564-2497
Emmanuelle Le BarsInstitut d'Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Gui de Chauliac Hospital and University of Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0002-3927-9868
Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-9264-5003
Meng LiDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.ORCID http://orcid.org/0000-0002-8320-5241
Elizabeth T C LippardDepartment of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-0528-3308
Carlos Lopez-JaramilloResearch Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellin, Colombia.
Ivan I MaximovNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-6319-6774
Andrew M McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Katie A McLaughlinBallmer Institute for Children's Behavioral Health, University of Oregon, Eugene, OR, USA.
Sean R McWhinneyDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-2177-7161
Elisa MelloniDivision of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Philip B MitchellDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.ORCID http://orcid.org/0000-0002-7954-5235
Benson MwangiLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Igor NenadićDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0749-7473
Stener NerlandNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-8771-8856
Emilie OlieDepartment of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0001-6684-8141
Victor Ortiz-García de la FozDepartment of Psychiatry. Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.ORCID http://orcid.org/0000-0002-0627-1827
Pedro M PanUniversidade Federal de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1943-6520
Fabricio PereiraMIPA, Université de Nîmes, Nimes, France.
Fabrizio PirasLaboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0003-3566-5494
Federica PirasLaboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy.ORCID http://orcid.org/0000-0002-9546-7038
Sara PolettiDivision of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0001-9594-0246
Andrew E ReinebergInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Gloria RobertsDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Rafael Romero-GarcíaDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Matthew D SacchetMeditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Giovanni A SalumChild Mind Institute, New York, NY, USA.
Anca-Larisa SanduAberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.ORCID http://orcid.org/0000-0002-5555-4129
Carl M SellgrenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9103-2785
Eiji ShimizuResearch Center for Child Mental Development, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0002-6741-9338
Harry R SmolkerInstitute for Cognitive Science, University of Colorado Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0003-3828-6676
Jair C SoaresLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5466-5628
J Douglas SteeleDivision of Imaging Science and Technology, Medical School, University of Dundee, Dundee, UK.
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-5052-6022
Dan J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Benjamin StraubeDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-9837-0944
Lea TeutenbergDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0003-4912-8307
Paula UsemannDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Romain ValabregueInstitut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.
Johanna Valencia-EcheverryResearch Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellin, Colombia.
Gerd WagnerDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.ORCID http://orcid.org/0000-0003-2296-0259
Gordon WaiterAberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
Martin WalterDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.ORCID http://orcid.org/0000-0001-7857-4483
Heather C WhalleyDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4505-8869
Mon-Ju WuLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0540-8027
Tony T YangDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Carlos A ZarateExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Andre ZugmanNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6126-7759
Giovana B Zunta-SoaresLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Kees van HeeringenGhent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-5801-194X
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0160-7248
Nic van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Steven van der WerffDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Hilary P BlumbergDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-6363-4698
Anne-Laura van HarmelenDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Miguel E RenteríaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-4626-7248
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
ENIGMA Suicidal Thoughts and Behaviours Consortium
Lianne SchmaalOrygen, Parkville, VIC, Australia.
Funding
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1MGlutamatergic Modulators for Rapid & Sustained Antidepressant EffectZIAMH002857 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2009 to 2025
$55.0MYale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8MColorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5MZOOMED FUNCT IMAGING IN HUMAN BRAIN AT 7T W/ SIMULT HIGH SPATIAL &TEMPORAL RESP41RR008079 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI UGURBIL, KAMIL · 1993 to 2011
$16.3M14/21 ABCD-USA Consortium: Research Project Site at CU BoulderU01DA051018 · NIDA · UNIVERSITY OF COLORADO · PI Marie T Banich, Naomi P. Friedman · 2020 to 2026
$11.4MNeurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR37MH119194 · NIMH · HARVARD UNIVERSITY · PI Katie McLaughlin · 2020 to 2026
$10.6MPsychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6MNeural Substrates of Executive Function: An fMRI Twin StudyR01MH063207 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI FRIEDMAN, NAOMI P. · 2001 to 2018
$6.5MChild Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8MLeveraging Latent Factors and Machine Learning to Forecast Internalizing Psychopathology in Emerging AdulthoodR01MH124846 · NIMH · UNIVERSITY OF COLORADO · PI ROSELINDE H KAISER, Hannah R. Snyder · 2022 to 2026
$3.5MENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3MGates Foundation INV-006732Intramural NIH HHS Z01 MH002857Intramural NIH HHS ZIA MH002857NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001872NCCIH NIH HHS R21 AT009173NCCIH NIH HHS R33 AT009864NCCIH NIH HHS R61 AT009864NCRR NIH HHS P41 RR008079NIA NIH HHS R01 AG046938NIA NIH HHS R01 AG058854NIDA NIH HHS R01 DA042742NIDA NIH HHS R01 DA046064NIDA NIH HHS U01 DA046413NIDA NIH HHS U01 DA051018NIMH NIH HHS K01 MH117442NIMH NIH HHS K23 MH090421NIMH NIH HHS R01 MH063207NIMH NIH HHS R01 MH069747NIMH NIH HHS R01 MH085667NIMH NIH HHS R01 MH085734NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117131NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH124846NIMH NIH HHS R01 MH125850NIMH NIH HHS R01 MH127176NIMH NIH HHS R01 MH129742NIMH NIH HHS R01 MH134004NIMH NIH HHS R21 MH130817NIMH NIH HHS R37 MH101495NIMH NIH HHS R37 MH119194NIMH NIH HHS R56 MH063207NIMH NIH HHS R56 MH117131NIMH NIH HHS RC1 MH088366U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) Intramural Research Program ZIA MH002857Wellcome Trust
Abstract
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity and radial diffusivity) for 24 WM tracts and one global measure were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt (n = 652; mean age = 35.4 ± 14.7; female = 71.8%), individuals with a psychiatric diagnosis but no STB (i.e., clinical controls; n = 1871; mean age = 34 ± 14.8; female = 59.8%), and individuals with no psychiatric diagnosis and no STB (i.e., healthy controls; n = 642; mean age = 29.6 ± 13.1; female = 62.9%). We also compared these measures among individuals with recent suicidal ideation (n = 714; mean age = 36.3 ± 15.3; female = 66.1%), clinical controls (n = 1184; mean age = 36.8 ± 15.6; female = 63.1%), and healthy controls (n = 1240; mean age = 31.6 ± 15.5; female = 61.0%). We found subtle but statistically significant effects, such as lower FA associated with a history of suicide attempt, over and above the effect of psychiatric diagnoses. These effects were strongest in the corona radiata, thalamic radiation, fornix/stria terminalis, corpus callosum and superior longitudinal fasciculus. Recent suicidal ideation was associated with higher AD in the cingulum. Effect sizes were small (partial eta-squared < 0.015). This large-scale coordinated mega-analysis revealed subtle regional and global alterations in WM microstructure in individuals with a history of suicide attempt and recent suicidal ideation. Longitudinal studies are needed to confirm whether these alterations are a risk factor for suicidal behaviour or ideation.
Indexed as
Mental DisordersSuicidal IdeationSuicide, AttemptedWhite MatterAdultAnisotropyDiffusion Tensor ImagingFemaleHumansMaleMiddle Aged
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