ArticleNature communications2025
Homeostasis of glucose and lipid metabolism during physiological responses to a simulated hypoxic high altitude environment.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Regulatory Role of Adrenomedullin in Hypoxic Adaptation of Yak Subcutaneous Preadipocytes.Animals : an open access journal from MDPI · 2026Article
- Altitude-Related Adaptation in Freshwater Snails (Animals : an open access journal from MDPI · 2026Article
- Dietary Bacillus sp. Modulates Multi-tissue Metabolism Through Gut Microbiota Remodeling in High-fat Fed Larimichthys crocea.Probiotics and antimicrobial proteins · 2026Article
- Association of the TyG-related indices with hypertension-diabetes comorbidity in middle-aged and older adults: a suburban community-based study.BMC cardiovascular disorders · 2026Article
- Study on Gut Microbiota Adaptation of Plateau Zokor (Microorganisms · 2026Article
- Lipid profile shift in high-altitude migrants as a key promoting factor for chronic myocardial injury revealed by lipidomics.Cell communication and signaling : CCS · 2026Article
- High altitude-mediated immune remodeling accelerates aging.Science advances · 2026Article
- High-Altitude Condition Induces Hepatic Magnetic Susceptibility Changes and Liver Injury.Biomolecules · 2026Article
- High-Altitude Hypoxia Injury: Systemic Mechanisms and Intervention Strategies on Immune and Inflammatory Responses.Antioxidants (Basel, Switzerland) · 2025Review
- Roles of Lipid Metabolism in Pulmonary Hypertension: Friend or Foe?Biomolecules · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
Homeostasis facilitates maintenance of physiological processes despite extrinsic fluctuations. In aerobic organisms, homeostasis is mainly fueled by metabolism of glucose and lipids, and requires oxygen as a metabolic substrate. Lack of oxygen can therefore trigger an imbalance of homeostasis in vivo. How animals living at high altitude hypoxic conditions can maintain homeostasis between the two types of metabolism remains largely unknown. Here, we establish a 'falconized' mouse model based on an adaptive EPAS1 genetic variant identified from saker falcons (Falco cherrug) on the Qinghai-Tibet Plateau (QTP). We show that homeostasis between glucose and lipid metabolism in the liver under chronic hypoxia is maintained in male falconized mice. This homeostasis is mediated by genetic factors and behavioral plasticity, resulting in higher survival rates even under acute hypoxia than wild type mice. Our study highlights a key role of metabolic homeostasis maintenance for survival in extreme environments, and provides potential targets for the treatment of associated metabolic diseases.
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