Evidence map›Paper›PMID 41136366›Full record

ReviewBlood cancer journal2025

35 years of academic trials focusing on high-dose therapy and autologous stem cell transplantation: the Intergroupe Francophone du Myélome (IFM) experience.

Philippe Moreau, Cyrille Hulin, Alexis Talbot, Hélène Demarquette, Léo Caillot, Thomas Chalopin, Arthur Bobin, Salomon Manier, Xavier Leleu, Lionel Karlin and 28 more

Abstract readReview
In one paragraph

Review in Blood cancer journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Blood cell-derived transplants at 40.Bone marrow transplantation · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Philippe MoreauUniversity Hospital Hôtel-Dieu, Nantes, France. philippe.moreau@chu-nantes.fr.ORCID 0000-0003-1780-8746
Cyrille HulinUniversity Hospital, Bordeaux, France.ORCID 0000-0002-3749-5161
Alexis TalbotUniversity Hospital Saint-Louis, Paris, France.ORCID 0000-0001-6734-413X
Hélène DemarquetteHospital of Dunkerque, Dunkirk, France.
Léo CaillotUniversity Hospital Saint-Louis, Paris, France.
Thomas ChalopinUniversity Hospital, Tours, France.ORCID 0000-0002-9833-3115
Arthur BobinUniversity Hospital, Poitiers, France.
Salomon ManierUniversity Hospital, Lille, France.
Xavier LeleuUniversity Hospital, Poitiers, France.ORCID 0000-0002-9822-4170
Lionel KarlinHospices Civils de Lyon, Lyon, France.
Denis CaillotPolyclinique du Parc Drevon, Dijon, France.ORCID 0009-0009-6985-5609
Cécile SonntagUniversity Hospital, Strasbourg, France.
Pierre FeugierUniversity Hospital, Nancy, France.
Murielle RousselUniversity Hospital, Limoges, France.
Romain GounotUniversity Hospital, Créteil, France.
Margaret MacroUniversity Hospital, Caen, France.
Mohamad MohtyUniversity Hospital Saint-Antoine, Paris, France.ORCID 0000-0002-7264-808X
Laurent GarderetUniversity Hospital La Pitié-Salpétrière, Paris, France.
Mourab TiabHospital of La Roche-sur-Yon, La Roche-sur-Yon, France.
Frédérique Orsini-PiocelleHospital of Annecy, Annecy, France.
Laure VincentUniversity Hospital, Montpellier, France.ORCID 0000-0001-5904-1286
Nathalie MeulemanInstitut Jules Bordet, Brussels, Belgium.
Jean FontanUniversity Hospital, Besançon, France.
Lidia MontesUniversity Hospital, Amiens, France.
Marie-Christiane VekemansCliniques Universitaires Saint-Luc, Brussels, Belgium.
Martine Escoffre-BarbeUniversity Hospital, Rennes, France.
Jean-Richard EveillardUniversity Hospital, Brest, France.
Jean-Marc Schiano de ColellaInstitut Paoli-Calmettes, Marseille, France.
Jérôme LambertUniversity Hospital Saint-Louis, Paris, France.
Jean-Yves MaryUniversity Hospital Saint-Louis, Paris, France.
Jean-Paul FermandUniversity Hospital Saint-Louis, Paris, France.
Bertrand ArnulfUniversity Hospital Saint-Louis, Paris, France.
Jill CorreUniversity Hospital, Toulouse, France.ORCID 0000-0003-1580-6106
Hervé Avet-LoiseauUniversity Hospital, Toulouse, France.
Thierry FaconUniversity Hospital, Lille, France.
Jean-Luc HarousseauInstitut Cancérologique de l'Ouest, Nantes, France.
Cyrille TouzeauUniversity Hospital Hôtel-Dieu, Nantes, France.ORCID 0000-0003-0275-2575
Aurore PerrotUniversity Hospital, Toulouse, France.ORCID 0000-0003-0131-8689

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frontline high-dose therapy (HDT) is, in 2025, the standard of care for patients with multiple myeloma (MM) who are eligible for autologous stem cell transplantation (ASCT). Prior to high-dose melphalan, induction therapy with quadruplet combinations is also proposed systematically when possible. Lenalidomide maintenance until progression is also recommended per international guidelines. This strategy has been developed over recent decades, based on results of phase 3 trials designed and conducted by different academic groups. With these therapeutic advances, the median overall survival (OS) for patients with MM has increased from 5 years in the 1990s, to over 15 years at present. Here, we present the contribution of the French myeloma cooperative group Intergroupe Francophone du Myélome (IFM) to these advances in the newly diagnosed transplant-eligible (NDTE) setting.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsHematopoietic Stem Cell TransplantationMultiple MyelomaClinical Trials as TopicHumansMelphalanTransplantation, AutologousMelphalan

Identifiers

PMID41136366
PMCPMC12552541

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.