Evidence map›Paper›PMID 41136361›Full record

ArticleTranslational psychiatry2025

Relationship between cortical thickness and serotonin 1A receptor binding in bipolar disorder.

Martin J Lan, Elizabeth Bartlett, Michael F Schmidt, Maria A Oquendo, Francesca Zanderigo, R Todd Ogden, J John Mann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Martin J LanDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA. martin.lan@nyspi.columbia.edu.ORCID http://orcid.org/0000-0002-9365-2758
Elizabeth BartlettDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
Michael F SchmidtDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
Maria A OquendoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Francesca ZanderigoDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6510-0676
R Todd OgdenDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.
J John MannDepartment of Psychiatry, Vagelos College of Physicians and Surgeons at Columbia University, New York, NY, USA.

Funding

Serotonin 1A Receptor PET Imaging and SSRI Outcome in Bipolar DepressionK23MH105688 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAN, MARTIN JOSEPH · 2014 to 2018
$930k
NIMH NIH HHS K23 MH105688U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH105688
6 · The paper itself

Abstract

Deficits in cortical thickness have been a replicated finding in BD. Greater brain serotonin 1 A receptor (5HT1AR) binding has also been reported in BD, consistent with a disruption in serotonin signaling. Serotonin can cause a trophic effect on the cerebral cortex. 31 depressed participants with BD and 49 healthy volunteers (HVs) were included. PET imaging with [

Indexed as

Bipolar DisorderBrain Cortical ThicknessCerebral CortexReceptor, Serotonin, 5-HT1AAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPiperazinesPositron-Emission TomographyPyridinesYoung AdultN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidePiperazinesPyridinesReceptor, Serotonin, 5-HT1A

Identifiers

PMID41136361
PMCPMC12552417

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.