Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jingyuan E ChenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA. jechen@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-3686-2983
Bruce R RosenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Laura Diane Lewis · 2022 to 2026
$13.6M
Project 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LINNINGER, ANDREAS A · 2021 to 2025
$13.4M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang, BRUCE R ROSEN · 2020 to 2026
$10.9M
Sleep-dependent Memory Processing in SchizophreniaR01MH092638 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DARA S MANOACH · 2012 to 2026
$7.4M
Resting state connectivity: Biophysical basis for and improved fMRI measurementsR01MH111438 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID, ROSEN, BRUCE R · 2016 to 2020
$5.2M
The neuropharmacology of brain activation during stages of drug abuseDP1DA058360 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI Christin Y. Sander · 2023 to 2026
$2.0M
Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataS10RR022976 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE · 2007 to 2007
$2.0M
Probing the Biophysical Basis of Large-Scale Brain Dynamics Using Simultaneous PET/fMRI and EEG/PET/fMRIR00NS118120 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JINGYUAN · 2023 to 2025
$735k
PET CAMERA FOR BRAIN IMAGING: SCHIZOPHRENIA, BIPOLAR DISORDERS10RR019933 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$500k
Multi-modal imaging of the metabolic and neurochemical mechanisms underlying task-evoked negative BOLD signalsR21MH135201 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JINGYUAN · 2024 to 2025
$459k
Probing the Biophysical Basis of Large-Scale Brain Dynamics Using Simultaneous PET/fMRI and EEG/PET/fMRIK99NS118120 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JINGYUAN · 2020 to 2021
$262k
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 31198BrightFocus Foundation (BrightFocus) A2023011SNCRR NIH HHS S10 RR019933NCRR NIH HHS S10 RR022976NIBIB NIH HHS P41 EB030006NIDA NIH HHS DP1 DA058360NIDDK NIH HHS P30 DK040561NIH HHS S10 OD010759NIMH NIH HHS R01 MH092638NIMH NIH HHS R01 MH111438NIMH NIH HHS R21 MH135201NINDS NIH HHS K99 NS118120NINDS NIH HHS R00 NS118120NINDS NIH HHS U19 NS123717NINDS NIH HHS U19 NS128613U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) P41-EB030006U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01-MH092638U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01-MH111438U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21-MH135201U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K99-NS118120U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R00-NS118120U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U19-NS123717U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U19-NS128613
6 · The paper itself
Abstract
Sleep entails significant changes in cerebral hemodynamics and metabolism. Yet, the way these processes evolve throughout wakefulness and sleep and their spatiotemporal dependence remain largely unknown. Here, by integrating a functional PET technique with simultaneous EEG-fMRI, we reveal a tightly coupled temporal progression of global hemodynamics and metabolism during the descent into NREM sleep, with large hemodynamic fluctuations emerging as global glucose metabolism declines, both of which track EEG arousal dynamics. Furthermore, we identify two distinct network patterns that emerge during NREM sleep: a ~0.02-Hz oscillating, high-metabolism sensorimotor network remains active and dynamic, whereas hemodynamic and metabolic activity in the default-mode network is suppressed. These results elucidate how sleep diminishes awareness while preserving sensory responses, and uncover a complex, alternating balance of neuronal, hemodynamic, and metabolic dynamics in the sleeping brain. This work also demonstrates the potential of EEG-PET-MRI to explore neuro-metabolic-hemodynamic mechanisms underlying cognition and arousal in humans.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep. · full record | OpenQuestion