Evidence map›Paper›PMID 41136339›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Dopamine and Temporal Discounting: Revisiting Pharmacology and Individual Differences.

Elke Smith, Hendrik Theis, Thilo van Eimeren, Kilian Knauth, Deniz Tuzsus, Lei Zhang, David Mathar, Jan Peters

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Sense of agency and decision making.Frontiers in psychology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elke SmithDepartment of Psychology, Biological Psychology, University of Cologne, Cologne 50969, Germany e.smith@uni-koeln.de.ORCID 0000-0003-2836-0924
Hendrik TheisDepartments of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany.ORCID 0000-0003-4661-5994
Thilo van EimerenDepartments of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne 50937, Germany.ORCID 0000-0002-6951-2325
Kilian KnauthDepartment of Psychology, Biological Psychology, University of Cologne, Cologne 50969, Germany.ORCID 0000-0002-4002-4651
Deniz TuzsusDepartment of Psychology, Biological Psychology, University of Cologne, Cologne 50969, Germany.ORCID 0000-0002-0825-5222
Lei ZhangCentre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham B15 2TT, United Kingdom.ORCID 0000-0002-9586-595X
David MatharDepartment of Psychology, Biological Psychology, University of Cologne, Cologne 50969, Germany.ORCID 0000-0003-3411-7867
Jan PetersDepartment of Psychology, Biological Psychology, University of Cologne, Cologne 50969, Germany.ORCID 0000-0002-0195-5357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders characterized by changes in dopamine (DA) neurotransmission are often linked to changes in the temporal discounting of future rewards. Likewise, pharmacological manipulations of DA neurotransmission in healthy individuals modulate temporal discounting, but there is considerable variability in the directionality of reported pharmacological effects, as enhancements and reductions of DA signaling have been linked to both increases and reductions of temporal discounting. This may be due to meaningful individual differences in drug effects and/or false-positive findings in small samples. To resolve these inconsistencies, we (1) revisited pharmacological effects of the DA precursor l-DOPA on temporal discounting in a large sample of

Indexed as

Delay DiscountingDopamineDopamine AgentsIndividualityLevodopaAdultBayes TheoremDouble-Blind MethodFemaleHumansMaleMiddle AgedRewardYoung AdultDopamineDopamine AgentsLevodopadopamineimpulsive choiceindividual differencesl-DOPAtemporal discounting

Identifiers

PMID41136339
PMCPMC12677122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.