Evidence map›Paper›PMID 41136031›Full record

ArticleJACC. Case reports2025

Concomitant Transapical Double Valve Replacement for Severe Native Mitral Regurgitation and Aortic Transcatheter Valve Degeneration.

Hristian Hinkov, Daniel Schwarzkopf, Dustin Greve, Sebastian Böhmel, Chong Bin Lee, Marian Kukucka, Jörg Kempfert, Christoph Klein, Axel Unbehaun

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hristian HinkovDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Structural Heart Interventions Program, Deutsches Herzzentrum der Charité, Berlin, Germany; German Center for Cardiovascular Research, Partner Site Berlin, Berlin, Germany. Electronic address: hristian.hinkov@dhzc-charite.de.
Daniel SchwarzkopfDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Dustin GreveDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sebastian BöhmelDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Chong Bin LeeCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Structural Heart Interventions Program, Deutsches Herzzentrum der Charité, Berlin, Germany; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Marian KukuckaCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Structural Heart Interventions Program, Deutsches Herzzentrum der Charité, Berlin, Germany; Department of Cardiac Anaesthesiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Jörg KempfertDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Christoph KleinCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Structural Heart Interventions Program, Deutsches Herzzentrum der Charité, Berlin, Germany; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany.
Axel UnbehaunDepartment of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité, Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Structural Heart Interventions Program, Deutsches Herzzentrum der Charité, Berlin, Germany; German Center for Cardiovascular Research, Partner Site Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter double valve replacement is an evolving strategy for managing combined mitral and aortic valve disease, particularly in patients with bioprosthetic valve degeneration. CASE SUMMARY: We report the case of an octogenarian with severe native mitral regurgitation and stenosis of a degenerated transcatheter aortic valve. Comorbid conditions, including extensive peripheral and coronary artery disease, limited conventional surgical and transcatheter access options. A tailored approach involving single-stage transapical implantation of a balloon-expandable aortic prosthesis and a dedicated mitral system resulted in favorable hemodynamic and clinical outcome. DISCUSSION: This case represents the first published use of dedicated transcatheter mitral device in combination with transcatheter-valve-in-transcatheter-valve replacement. It underscores the potential of fully catheter-based double valve therapy in challenging scenarios. TAKE-HOME MESSAGES: Transapical transcatheter double valve replacement offers a viable alternative to redo surgery in select patients. Procedural success hinges on imaging-guided planning and individualized device strategy.

Indexed as

SVDTAVRTDVRTMVRtranscatheter double valve replacement

Identifiers

PMID41136031
PMCPMC12789791

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.