Evidence map›Paper›PMID 41135584›Full record

ArticleApplied clinical informatics2025

Identifying Pediatric Long COVID: Comparing an EHR Algorithm to Manual Review.

Morgan Botdorf, Kimberley Dickinson, Vitaly Lorman, Hanieh Razzaghi, Nicole Marchesani, Suchitra Rao, Colin Rogerson, Miranda Higginbotham, Asuncion Mejias, Daria Salyakina and 12 more

Abstract readComparative Study
In one paragraph

Article in Applied clinical informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Morgan BotdorfApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Kimberley DickinsonApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Vitaly LormanApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Hanieh RazzaghiApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Nicole MarchesaniApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Suchitra RaoDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Denver, Colorado, United States.
Colin RogersonDivision of Critical Care, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Miranda HigginbothamApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
Asuncion MejiasDivision of Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, United States.
Daria SalyakinaCenter for Precision Medicine, Nicklaus Children's Hospital, Miami, Florida, United States.
Deepika ThackerNemours Cardiac Center, Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States.
Dima DandachiDivision of Infectious Diseases, Department of Medicine, University of Missouri-Columbia, Columbia, Missouri, United States.
Dimitri A ChristakisCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, United States.
Emily TaylorNew York University Grossman School of Medicine, RECOVER Patient, Caregiver, or Community Representative, New York, New York, United States.
Hayden T SchwenkDivision of Pediatric Infectious Diseases, Stanford School of Medicine, Palo Alto, California, United States.
Hiroki MorizonoCenter for Genetic Medicine Research, Children's National Hospital, Washington, District of Columbia, United States.
Jonathan D CogenDivision of Pulmonary and Sleep Medicine, Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington, United States.
Nathan M PajorDivision of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.
Ravi JhaveriDivision of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States.
Christopher B ForrestApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
L Charles BaileyApplied Clinical Research Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States.
RECOVER Consortium

Funding

NIH Researching COVID to Enhance Recovery (RECOVER) Initiative OT2HL161847-01
6 · The paper itself

Abstract

Long COVID, characterized by persistent or recurring symptoms post-COVID-19 infection, poses challenges for pediatric care and research due to the lack of a standardized clinical definition. Adult-focused phenotypes do not translate well to children, given developmental and physiological differences, and pediatric-specific phenotypes have not been compared with chart review.This study introduces and evaluates a pediatric-specific rule-based computable phenotype (CP) to identify long COVID using electronic health record data. We compare its performance to manual chart review.We applied the CP, composed of diagnostic codes empirically associated with long COVID, to 339,467 pediatric patients with SARS-CoV-2 infection in the RECOVER PCORnet EHR database. The CP identified 31,781 patients with long COVID. Clinicians conducted chart reviews on a subset of patients across 16 hospital systems to assess performance. We qualitatively reviewed discordant cases to understand differences between CP and clinician identification.Among the 651 reviewed patients (339 females,

Indexed as

AlgorithmsCOVID-19Electronic Health RecordsAdolescentChildChild, PreschoolFemaleHumansMaleSARS-CoV-2

Identifiers

PMID41135584
PMCPMC12552067

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.