Evidence map›Paper›PMID 41135093›Full record

ReviewAging and disease2025

Metabolic-Inflammatory Syndrome: Decoding the Metabolic-Immune Axis for Precision Intervention.

Simin Li, Yawei Shi, Chongge You

Abstract readReview
In one paragraph

Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Simin LiLaboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China.
Yawei ShiDepartment of Pathology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China.
Chongge YouLaboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic-inflammatory syndrome represents a major global health challenge, closely linked to diabetes, cardiovascular disease, obesity, and non-alcoholic fatty liver disease. The core of these disorders involves remodeling of metabolic pathways under nutritional stress and the ensuing chronic inflammatory vicious cycle. This review systematically examines the mechanisms by which metabolic reprogramming drives metabolic-inflammatory syndrome, revealing the significant role of the gut microbiota in this process. Furthermore, it evaluates current metabolic-inflammatory syndrome early-warning systems and proposes innovative therapeutic strategies precisely targeting the metabolic-immune axis, establishing a foundation for enhancing early detection and clinical intervention.

Indexed as

InflammationMetabolic SyndromeAnimalsGastrointestinal MicrobiomeHumansMetabolic ReprogrammingPrecision Medicine

Identifiers

PMID41135093
PMCPMC13653731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.