Evidence map›Paper›PMID 41135092›Full record

ArticleAging and disease2025

The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity.

Myriam Rahmouni, Cristina Giuliani, Daniela Colucci, Nicolás Mendoza-Mejía, Samuel Hiet, Marco Lamanda, Jean-Louis Spadoni, Sigrid Le Clerc, Taoufik Labib, Matilde Manetti and 10 more

Abstract read
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In one paragraph

Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Myriam RahmouniLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Cristina GiulianiLaboratory of Molecular Anthropology, Department of Biological, Geological and Environmental Sciences (BiGeA), University of Bologna, Bologna, Italy.
Daniela ColucciLaboratory of Molecular Anthropology, Department of Biological, Geological and Environmental Sciences (BiGeA), University of Bologna, Bologna, Italy.
Nicolás Mendoza-MejíaInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Samuel HietLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Marco LamandaLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Jean-Louis SpadoniLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Sigrid Le ClercLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Taoufik LabibLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Matilde ManettiLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Maxime TisonLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Raissa Medina-SantosLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.
Paolo GaragnaniIRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Alexandre How-KitLaboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France.
Armand BensussanUnité INSERM U976, Hôpital Saint-Louis, Paris, France.
Marianne NygaardEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Kaare ChristensenDepartment of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Jean-François DeleuzeLaboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France.
Jean-François ZaguryLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our recent research on AIDS Elite controllers, we demonstrated that the HLA-B*57:01 allele is part of an extensive MHC haplotype associated with impaired MICA/MICB function. Considering the pivotal role of natural killer (NK) cells and innate immunity in fighting cancer and infectious diseases, we investigated whether this allele could also influence human longevity. To this end, we performed a multinational European study including 2,597 centenarians and 9,973 controls. We found that HLA-B*57:01 was consistently less frequent in the European centenarian cohorts compared with the corresponding controls (OR ≈ 0.68, p < 0.0005). These findings provide the first in vivo genetic evidence that innate immunity and NK cell function are key components of human longevity.

Indexed as

HaplotypesHLA-B AntigensImmunity, InnateLongevityAged, 80 and overCase-Control StudiesFemaleGene FrequencyHumansKiller Cells, NaturalMaleHLA-B57 antigenHLA-B Antigens

Identifiers

PMID41135092
PMCPMC13653734

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.