Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Ying YangDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-9946-2640
Da Eun KangDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0009-0002-1251-0318
Qi FanDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Eric A HanseDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Hosung BaeDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-5848-7972
Rocio A BarahonaDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-1654-6377
Xiyu ShenDepartment of Medicine, Physiology and Biophysics, and Diabetes Center, School of Medicine, University of California, Irvine, Irvine, CA 92617, USA.
Bryan I RuizDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-3278-4770
Shelly H LeeDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Katherine R PasterczykDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0009-0006-6114-3541
Nainpriya BabbarDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Katherine G WaldvogelDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0009-0008-2334-7396
Roberto TinocoDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-5420-9692
Kim N GreenDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-6049-6744
Qin YangDepartment of Medicine, Physiology and Biophysics, and Diabetes Center, School of Medicine, University of California, Irvine, Irvine, CA 92617, USA.ORCID 0000-0002-7581-5410
Cholsoon JangDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-6651-4213
Mei KongDepartment of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-8139-2349
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0M
Protein Phosphatase Control of AMPK FunctionR01GM132142 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KONG, MEI · 2019 to 2023
$1.2M
Regulatory Mechanisms of PP2A Family PhosphatasesR35GM153227 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MEI KONG · 2024 to 2026
Aging is characterized by disruptions in metabolic homeostasis, yet the mechanisms that regulate these metabolic changes remain poorly understood. We show that the serine/threonine-protein phosphatase 6 (PP6) regulatory subunit 3, SAPS3, is a critical regulator of metabolism during aging. SAPS3 deletion significantly extends lifespan in mice and counteracts age-related impairments in metabolic health. SAPS3 deficiency improves the effects of aging on the affective behaviors, cognition, and motor functions in aged mice. We find that SAPS3 expression is increased during aging to inhibit adenosine monophosphate-activated kinase (AMPK) activity. Deletion of SAPS3 leads to AMPK activation and reverses cellular senescence and aging-induced metabolic alterations. Using in vivo U-
Indexed as
LongevityPhosphoprotein PhosphatasesAgingAMP-Activated Protein KinasesAnimalsCellular SenescenceCitric Acid CycleGlycolysisMiceMice, KnockoutAMP-Activated Protein KinasesPhosphoprotein Phosphatasesprotein phosphatase 6
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism. · full record | OpenQuestion