Evidence map›Paper›PMID 41134904›Full record

ArticleScience advances2025

Metabolic regulation of behavior by the intestinal enzyme FMO-2.

Elizabeth S Kitto, Safa Beydoun, Ella Henry, Megan L Schaller, Mira Bhandari, Sarah A Easow, Angela M Tuckowski, Marshall B Howington, Ajay Bhat, Aditya Sridhar and 3 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elizabeth S KittoMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-3414-1509
Safa BeydounMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-8068-3953
Ella HenryMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.
Megan L SchallerMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4347-8701
Mira BhandariMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0009-0006-4143-2522
Sarah A EasowMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0849-8363
Angela M TuckowskiMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9125-4780
Marshall B HowingtonMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.
Ajay BhatMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5021-0864
Aditya SridharMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.
Eugene ChungMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.
Charles R EvansBiomedical Research Core Facilities Metabolomics Core, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6698-5330
Scott F LeiserMolecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8003-2955

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Flavin-containing monooxygenases in endogenous metabolism and agingR01AG075061 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT F LEISER · 2022 to 2026
$2.1M
Mechanisms of the cell non-autonomous dietary restriction pathwayR01AG059583 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEISER, SCOTT F · 2018 to 2022
$1.9M
Mechanistic understanding of host-microbe interactions in regulating stress response and lifespanK99AG083058 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BHAT, AJAY · 2024 to 2025
$234k
Determining the neural mechanisms of mechanosensory food perception in DR-mediated longevityF31AG084146 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KITTO, ELIZABETH SARAH · 2023 to 2024
$83k
NIA NIH HHS F31 AG084146NIA NIH HHS K99 AG083058NIA NIH HHS P30 AG024824NIA NIH HHS R01 AG059583NIA NIH HHS R01 AG075061
6 · The paper itself

Abstract

Many elements of an organism's behavior are intertwined with the organism's health. Over a long period of time, health status is also indicative of life span, with improved health correlating with a longer life. However, the relationship between longevity and behavior remains relatively unexplored. Here, we report that modification of a single longevity gene downstream of dietary restriction and hypoxia markedly alters behavior in

Indexed as

Behavior, AnimalCaenorhabditis elegansCaenorhabditis elegans ProteinsIntestinal MucosaIntestinesOxygenasesAnimalsLongevitySerotoninSignal TransductionTryptophanCaenorhabditis elegans Proteinsdimethylaniline monooxygenase (N-oxide forming)OxygenasesSerotoninTryptophan

Identifiers

PMID41134904
PMCPMC12551704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.