Evidence map›Paper›PMID 41134902›Full record

ArticleScience advances2025

Transgenerational adaptation to hypoxia.

Kathleen Kim, Ariel Telger, Gautam Sarkar, Sharan Surya, M Hafiz Rothi, Michael P Meers, Simon Yuan Wang, Eric Lieberman Greer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kathleen KimDepartment of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4214-7778
Ariel TelgerDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1266-8396
Gautam SarkarDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sharan SuryaDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0009-7078-5433
M Hafiz RothiDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-7301-4719
Michael P MeersDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-3438-3938
Simon Yuan WangDepartment of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9089-2617
Eric Lieberman GreerDepartment of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7501-7371

Funding

Characterization of DNA N6-methyl adenine and its role in epigenetic memoryDP2AG055947 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2016 to 2021
$3.2M
Ribosomal RNA Methylation Regulation of Longevity and Stress ResistanceR01AG084739 · NIA · WASHINGTON UNIVERSITY · PI Eric Lieberman Greer · 2023 to 2026
$2.2M
Ribosomal RNA methylation regulation of longevity and stress resistanceR56AG076496 · NIA · WASHINGTON UNIVERSITY · PI GREER, ERIC LIEBERMAN · 2022 to 2022
$322k
NIA NIH HHS DP2 AG055947NIA NIH HHS R01 AG084739NIA NIH HHS R56 AG076496
6 · The paper itself

Abstract

Epigenetic inheritance alerts naïve descendants to prepare for stresses that could still be present, whereas distant descendants return to a basal state after several generations without stress. However, organisms are frequently exposed to stresses successively across generations. We found that parental hypoxia exposure increased P0 longevity, caused intergenerational lipid reduction, and elicited transgenerational fertility reduction that was dependent on generationally transmitted small RNAs. Here, we find that

Indexed as

Adaptation, PhysiologicalCaenorhabditis elegansHypoxiaAnimalsCaenorhabditis elegans ProteinsEpigenesis, GeneticFertilityHistonesLongevityCaenorhabditis elegans ProteinsHistones

Identifiers

PMID41134902
PMCPMC12551719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.