Evidence map›Paper›PMID 41134900›Full record

ArticleScience advances2025

Sustainable synthesis of amino-cellulose nanofibers for biomaterial platforms.

Xiaochao Shi, Jian Zhang, Weixin Guan, Cong Li, Wenshuai Chen, Guihua Yu, Haipeng Yu

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaochao ShiState Key Laboratory of Woody Oil Resources Utilization; Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China.ORCID 0009-0001-3195-3096
Jian ZhangBiofunctional Experiment Teaching Center, Harbin Medical University, Harbin 150081, China.
Weixin GuanMaterials Science and Engineering Program and Walker Department of Mechanical Engineering, University of Texas at Austin, TX, USA.ORCID 0000-0003-3779-6308
Cong LiState Key Laboratory of Woody Oil Resources Utilization; Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China.ORCID 0009-0003-1874-8885
Wenshuai ChenState Key Laboratory of Woody Oil Resources Utilization; Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0003-4428-1505
Guihua YuMaterials Science and Engineering Program and Walker Department of Mechanical Engineering, University of Texas at Austin, TX, USA.ORCID 0000-0002-3253-0749
Haipeng YuState Key Laboratory of Woody Oil Resources Utilization; Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China.ORCID 0000-0003-0634-7913

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing demand for sustainable materials has driven interest in harnessing renewable resources to develop advanced biomaterials. Cellulose nanofibers, derived from abundant natural reserves, offer excellent mechanical strength and thermal stability but lack inherent biofunctionality. This study presents a method that is green, cost-effective, and scalable to synthesize amino-cellulose nanofibers (A-CNFs) by grafting carboxyl groups and thereon amino groups onto cellulose, followed by ultrasonic nanofibrillation, resulting in ultrafine, lengthy A-CNF with enhanced mechanical properties, biocompatibility, and antibacterial activity. Comparative analyses demonstrate that A-CNF scaffolds exhibit favorable biostability, pore connectivity, and mechanical integrity in tissue engineering applications. Biological assessments further indicate improved cell viability and reduced hemolysis, underscoring A-CNF's potential as robust, biocompatible, and sustainable material platforms for biomedical use.

Indexed as

Biocompatible MaterialsCelluloseNanofibersAnimalsAnti-Bacterial AgentsCell SurvivalHumansMaterials TestingTissue EngineeringTissue ScaffoldsAnti-Bacterial AgentsBiocompatible MaterialsCellulose

Identifiers

PMID41134900
PMCPMC12551711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.