ArticleScience advances2025
Lightweight multiscale early warning system for influenza A spillovers.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Closed-Loop digital therapeutics empowered by deep reinforcement learning and wearable sensing for precision orthopedic rehabilitation: a simulation-based proof-of-concept study.Frontiers in rehabilitation sciences · 2026Review
- Influenza A Virus H5N1 Subtype: Resurgent Interspecies and Intercontinental Transmission, and a New Host.Pathogens (Basel, Switzerland) · 2025Review
- Lightweight multiscale early warning system for influenza A spillovers.Science advances · 2025Article
- A codon usage-based approach for the stratification of Influenza A across recent spillovers.Computational and structural biotechnology journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spillovers of zoonotic Influenza A viruses (IAVs) into farmed animals and humans have the potential to trigger epidemics or even global pandemics. We introduce FluWarning, a highly efficient and elegant computational method based on anomaly detection of codon bias and dinucleotide composition for early identification of divergent viral HA segments. We applied FluWarning to the 2009 influenza pandemic as a test case. FluWarning successfully identified the emergence of pdm09, the virus that caused the pandemic, with warnings preceding the observed global spread. Applied to H5N1 specimens collected between 2019 and 2025, FluWarning flagged genotypes D1.1 and B3.13, both associated with recent spillovers in dairy cows in the United States. In summary, FluWarning is an effective, lightweight, multiscale warning system for IAVs, detecting spillovers with few available sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.