Evidence map›Paper›PMID 41134897›Full record

ArticleScience advances2025

β-Acyloxyl alkenyl amide synthesis via multiple defluorination: α-Trifluoromethyl ketone-amine as synergystic peptide coupling reagent.

Sufang Cao, Haijin Guo, Zukang Zhong, Demao Chen, Wenli Song, Yunyun Liu, Jie-Ping Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sufang CaoCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.ORCID 0009-0007-5704-744X
Haijin GuoCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.ORCID 0009-0005-2066-5995
Zukang ZhongCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.
Demao ChenCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.
Wenli SongCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.
Yunyun LiuCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.ORCID 0000-0002-5553-1672
Jie-Ping WanCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.ORCID 0000-0002-9367-8384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-Acyloxyl alkenyl amides (AAAs) are vinylogous esters with high activity toward acylation reactions. However, only one synthetic procedure consisting of five independent operation steps involving highly sensitive amino alkynone intermediate is available for their synthesis to date, depressing rigidly the application of AAAs in peptide synthesis and expanded acylation reactions. Herein, by combining consecutive trifold defluorination, acyl migration, and multicomponent reactions, a considerably simpler one-step protocol has been established for AAA synthesis with the α-trifluoromethyl ketones, amines, and carboxylic acids/amino acids as starting materials using Cs

Identifiers

PMID41134897
PMCPMC12551715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.