Evidence map›Paper›PMID 41134891›Full record

ArticleScience advances2025

Programmed ribosomal frameshifting during

Gary Loughran, Raffaella De Pace, Ningyu Ding, Jianchao Zhang, Irwin Jungreis, Gionmattia Carancini, Jonathan M Mudge, Ji Wang, Manolis Kellis, John F Atkins and 5 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Gary LoughranSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.ORCID 0000-0002-2683-5597
Raffaella De PaceDivision of Neuroscience & Cellular Structure, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8179-6869
Ningyu DingDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Republic of China.ORCID 0009-0007-1560-2978
Jianchao ZhangDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Republic of China.
Irwin JungreisMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.ORCID 0000-0002-3197-5367
Gionmattia CaranciniSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.
Jonathan M MudgeEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton CB10 1SD Cambridge, UK.ORCID 0000-0003-4789-7495
Ji WangDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0009-0001-5220-3358
Manolis KellisMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.ORCID 0000-0001-7113-9630
John F AtkinsSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.ORCID 0000-0001-7933-0165
Pavel V BaranovSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland.ORCID 0000-0001-9017-0270
Andrew E FirthDepartment of Pathology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7986-9520
Xiaowei LiDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, Republic of China.ORCID 0009-0005-9996-1999
Juan S BonifacinoDivision of Neuroscience & Cellular Structure, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5673-6370
Yousuf A KhanDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0201-2796

Funding

Protein Trafficking In The Endosomal-Lysosomal SystemZIAHD001607 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BONIFACINO, JUAN · 2009 to 2025
$48.3M
GENCODE: comprehensive reference genome annotation for human and mouseU24HG007234 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Fergal James Martin · 2021 to 2026
$16.1M
REGULATION OF THE FATE OF NEWLY SYNTHESIZED PROTEINSZ01HD001607 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BONIFACINO, JUAN · 1991 to 2008
$4.4M
Deciphering the principles and mechanism of RNA structureDP5OD039455 · OD · STANFORD UNIVERSITY · PI Yousuf A Khan · 2025 to 2026
$770k
Mechanistic Principles of SNARE Disassembly in Neurotransmitter ReleaseF31MH134477 · NIMH · STANFORD UNIVERSITY · PI KHAN, YOUSUF A · 2023 to 2025
$84k
Intramural NIH HHS Z01 HD001607Intramural NIH HHS ZIA HD001607NHGRI NIH HHS U24 HG007234NIH HHS DP5 OD039455NIMH NIH HHS F31 MH134477Wellcome Trust
6 · The paper itself

Abstract

Programmed ribosomal frameshifting is a process where a proportion of ribosomes change their reading frame on an mRNA. While frameshifting is commonly used by viruses, very few phylogenetically conserved examples are known in nuclear encoded genes. Here, we report a +1 frameshifting event during decoding of the human gene

Indexed as

Frameshifting, RibosomalMyocardiumMyocytes, CardiacRNA, MessengerAnimalsHumansProtein BiosynthesisRibosomesRNA, Messenger

Identifiers

PMID41134891
PMCPMC12551717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.