Evidence map›Paper›PMID 41134890›Full record

ArticleScience advances2025

Biosensor-driven strain engineering reveals key cellular processes for maximizing isoprenol production in

Javier Menasalvas, Shawn Kulakowski, Yan Chen, Jennifer W Gin, Emine Akyuz Turumtay, Nawa Raj Baral, Morgan A Apolonio, Alex Rivier, Ian S Yunus, Megan E Garber and 8 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Functional organization and regulatory logic of theApplied and environmental microbiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Javier MenasalvasThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-4003-4999
Shawn KulakowskiThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.
Yan ChenThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-1125-313X
Jennifer W GinThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0001-5636-7563
Emine Akyuz TurumtayThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-1504-4810
Nawa Raj BaralThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-0942-9183
Morgan A ApolonioThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-1458-3708
Alex RivierThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.
Ian S YunusThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-2395-0821
Megan E GarberThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.
Corinne D ScownThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.
Paul D AdamsThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0001-9333-8219
Taek Soon LeeThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-0764-2626
Ian K BlabyUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID 0000-0002-1631-3154
Edward E K BaidooThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0001-5787-1219
Christopher J PetzoldThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-8270-5228
Thomas EngThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-4974-3863
Aindrila MukhopadhyayThe Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA 94608, USA.ORCID 0000-0002-6513-7425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic biology generates vast combinatorial designs, yet high-throughput analytical methods to screen them are poorly matched to interrogate this search space. We address this challenge by developing a biosensor-driven, growth-coupled selection strategy in

Indexed as

Biosensing TechniquesHemiterpenesMetabolic EngineeringPseudomonas putidaAlcohol DehydrogenaseBacterial ProteinsHistidine KinaseSignal TransductionSynthetic BiologyAlcohol DehydrogenaseBacterial ProteinsHemiterpenesHistidine Kinase

Identifiers

PMID41134890
PMCPMC12551699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.