In one paragraphArticle in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
29 authors.
René WinklerProgram of Applied Epigenetics, Program of Myeloid Neoplasms, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, Badalona, Spain.ORCID 0000-0002-7570-0242 Gemma Comas-ArmanguéInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-6359-1053 David CorujoProgram of Applied Epigenetics, Program of Myeloid Neoplasms, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, Badalona, Spain.ORCID 0000-0001-7930-0935 Adrián Sanz-MorenoInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-9478-5432 Julia Calzada-WackInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-0816-9305 Shubhra Ashish BhattacharyaProgram of Applied Epigenetics, Program of Myeloid Neoplasms, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, Badalona, Spain.ORCID 0000-0003-1540-7957 Birgit RathkolbInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-1239-0547 Nathalia Romanelli Vicente DraganoInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
Colina X QiaoDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0001-3832-2019 Valentina ChiodiIstituto Superiore di Sanità, National Centre for Drug Research and Evaluation, 00161 Rome, Italy.ORCID 0000-0002-9783-0005 Dan FilipescuDepartment of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6381-2557 Dylan H ParkDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Maria Rosaria DomeniciIstituto Superiore di Sanità, National Centre for Drug Research and Evaluation, 00161 Rome, Italy.ORCID 0000-0001-5552-4061 Valentina Kirigin CallaúDepartment of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Raffaele GerliniInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0003-0852-5621 Jan RozmanInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-8035-8904 Tanja Klein-RodewaldInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
Antonio Aguilar-PimentelInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
Lore BeckerInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-6890-4984 Claudia SeisenbergerInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-6430-2732 Susan MarschallInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-5191-7060 Helmut FuchsInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.
Valérie Gailus-DurnerInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-6076-0111 Emily BernsteinDepartment of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6533-8326 Manlio VinciguerraDepartment of Translational Stem Cell Biology, Research Institute of the Medical University, Varna, Bulgaria.ORCID 0000-0002-1768-3894 Philipp OberdoerfferDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2484-1440 Martin Hrabě de AngelisInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-7898-2353 Raffaele TeperinoInstitute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0001-8815-1409 Marcus BuschbeckProgram of Applied Epigenetics, Program of Myeloid Neoplasms, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, Badalona, Spain.ORCID 0000-0002-3218-4567 Funding
Deciphering the tumor suppressive functions of macroH2AR01CA154683 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERNSTEIN, EMILY · 2011 to 2021
$3.9MEpigenetic mechanisms controlling single-stranded DNA lesion sensitivity and mutagenesisR01CA285725 · NCI · JOHNS HOPKINS UNIVERSITY · PI Philipp Oberdoerffer · 2024 to 2026
$2.6MProbing the mechanisms that control DNA repair pathway choice.R35GM153484 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Philipp Oberdoerffer · 2024 to 2026
$1.5MNCI NIH HHS R01 CA154683NCI NIH HHS R01 CA285725NIGMS NIH HHS R35 GM153484
6 · The paper itselfAbstract
Histone variants with metabolite-binding macrodomains provide a poorly understood link between chromatin composition and metabolism. To address their contribution to physiological health, we generated and analyzed mice individually lacking the histone variants macroH2A1.1, macroH2A1.2, or macroH2A2. We identified several histopathologic changes in the kidney as isoform-specific phenotype of complete macroH2A1.1 loss affecting male and female animals. Kidney alterations were barely associated with organ-intrinsic gene expression changes but strongly correlated with a systemic shift in nutrient metabolization and alterations in NAD
Indexed as
HistonesKidneyNutrientsAnimalsFemaleGlycolysisLipid MetabolismLiverMaleMiceMice, KnockoutHistonesmacroH2A histoneNutrients
Identifiers
PMID41134882
PMCPMC12551714
What OpenQuestion holds
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LicenceCC BY-NC
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