Evidence map›Paper›PMID 41134876›Full record

ArticleScience immunology2025

Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells.

Jordy Saravia, Nicole M Chapman, Yu Sun, Xiaoxi Meng, Isabel Risch, Wei Li, Cliff Guy, Hao Shi, Haoran Hu, Yogesh Dhungana and 11 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Resetting immunometabolic set points in autoimmune disease.Journal of translational autoimmunity · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Metabolic adaptation in CD4Nature immunology · 2026
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jordy SaraviaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-2691-501X
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-4710-1776
Yu SunDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0009-0002-3927-1396
Xiaoxi MengDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-7217-2037
Isabel RischDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-3356-0349
Wei LiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0009-0003-4681-4923
Cliff GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-7486-7107
Hao ShiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-2796-629X
Haoran HuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yogesh DhunganaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-4021-0075
Jia LiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zhiyuan YouDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-9833-7485
Anil KcDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Seon Ah LimDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-6560-4874
Jana L RaynorDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-5192-0654
Sharad ShresthaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Erienne G NortonDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-3611-3205
Sarah E La GrangeCell and Tissue Imaging Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Camenzind G RobinsonCell and Tissue Imaging Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-7277-692X
Peter VogelDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-7535-0545
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-9997-2496

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Integrating systems immunology with immunometabolism and cancer immunityR35CA253188 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2021 to 2026
$6.0M
Regulation of TH17 plasticity and stemness by mTORC1R01AI131703 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$4.1M
Transcriptional and metabolic heterogeneity in T cell differentiationR01AI140761 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$3.9M
Metabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6M
Bidirectional signaling in T cell differentiationR01AI150241 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.3M
Nutrient sensing and lysosomal signaling in regulatory T cells and immune toleranceR01AI150514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2019 to 2023
$2.2M
Metabolic checkpoint in TH17 cell differentiationR01AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$2.2M
NCI NIH HHS P30 CA021765NCI NIH HHS R35 CA253188NIAID NIH HHS R01 AI105887NIAID NIH HHS R01 AI131703NIAID NIH HHS R01 AI140761NIAID NIH HHS R01 AI150241NIAID NIH HHS R01 AI150514NIAID NIH HHS R37 AI105887
6 · The paper itself

Abstract

Immunotherapies targeting regulatory T (T

Indexed as

LysosomesMitochondriaSignal TransductionT-Lymphocytes, RegulatoryAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGTP PhosphohydrolasesMiceMice, Inbred C57BLMice, KnockoutBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGTP PhosphohydrolasesOpa1 protein, mouseTcfeb protein, mouse

Identifiers

PMID41134876
PMCPMC12947969

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.