ArticleJournal of natural products2025
Alkali Cation- and Borate-Binding States of Tartrolon Antibiotics.
Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
The borate-binding polyketide macrolide natural products are a long-known family of bacterial antibiotics and antiparasitic agents. Among these, tartrolon E is highly potent and selective in killing eukaryotic parasites while sparing mammalian cells. However, it has been challenging to obtain, fully chemically define, and formulate the tartrolons. Here, we describe a streamlined route to obtain pure tartrolon E as a highly crystalline material. The method yielded crystals of tartrolon E, the analysis of which revealed the stable chelation of a sodium counterion. Using this chemically defined material, additional experiments permitted quantitative cation exchange with alkali-metal cations, suggesting a relative binding affinity of Li
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