ArticlePloS one2025
Association between thyroid hormone and cardiovascular health: A cross-sectional study.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLarge-sample clinical research evidence in humans regarding the association between thyroid hormones and cardiovascular health is limited. The American Heart Association introduced the Life's Essential 8 (LE8) as a novel metric for assessing cardiovascular health. This study aimed to explore the plausible connection between thyroid hormone levels and LE8.
methodsThis study employed data extracted from the National Health and Nutrition Examination Survey spanning from 2007-2012, focusing on individuals aged 20 and above. To investigate the association between thyroid hormone and LE8, diverse analytical methods, including weighted multivariate linear regression, restricted cubic spline curves, and stratified analysis, were utilized.
resultsA total of 3,019 participants were enrolled in this study. The highest LE8 score group (≥ 80) comprised 610 participants (20.21%). In the fully adjusted linear regression analysis, elevated levels of ln(FT3), ln(TT3), and ln(Tg) were significantly associated with a reduced level of LE8 (β (95% Confidence Interval): -6.31 (-12.13, -0.49), p = 0.035; -5.18 (-8.22, -2.15), p = 0.002; -0.98 (-1.74, -0.22), p = 0.014). The analysis revealed nonlinear relationships between ln(Tg), ln(TgAb), ln(TPOAb), and LE8. In the group with normal thyroid hormone levels, ln(TT3), ln(TT4), and ln(Tg) correlated with LE8 in the stratified analysis.
conclusionAlterations in FT3, TT3, TT4, Tg, TgAb, and TPOAb levels correlated with variations in LE8. Adherence to cardiovascular health recommendations may be pertinent to the preservation of thyroid health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.