ArticleCancer medicine2025
Investigating Genomic Differences by Ethnicity in Breast, Colorectal and Prostate Cancers: Secondary Data Analysis of the Genomic Data Commons (GDC) Database.
Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGlobally, millions of cancer cases are diagnosed annually and mortality rates continue to rise with breast (BC), colorectal (CRC) and prostate (PC) cancer among the most prevalent. Race and ethnic disparities in cancer outcomes have been well-documented; however, the underlying factors contributing to these disparities are currently unknown.
designThis study utilised the Genomic Data Commons (GDC) Portal, a publicly accessible repository, therefore ethical approval was not required. Cancer incidence data were collected by prevalent gene mutations associated with BC, CRC and PC within White, Black and Asian populations. Rolling one-year survival rates were constructed for each genetic mutation.
resultsFor BC, Black and Asian individuals exhibited higher percentages of cases associated with TP53 mutations compared to Whites. CRC incidence showed Black individuals exhibited higher percentages of cases associated with APC, KRAS and PIK3CA mutations compared to Whites and Asians. PC incidence demonstrated that Black individuals had elevated percentages of cases associated with SPOP, ATM and SYNE1 mutations compared to Whites and Asians. Asian individuals displayed significantly lower survival percentages over 10 years compared to White and Black populations across genetic mutations associated with BC. White individuals exhibited significantly higher survival percentages over 10 years compared to Black individuals across genetic mutations associated with CRC.
conclusionSignificant disparities exist in cancer incidence and survival rates across White, Black and Asian populations. These findings demonstrate the importance of targeted approaches in cancer prevention, diagnosis and treatment to address disparities and the need for equitable healthcare. Further research is needed to identify mechanisms driving such disparities and to develop effective strategies to improve cancer outcomes across diverse ethnic populations.
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