Evidence map›Paper›PMID 41134549›Full record

ArticleBiochemistry2025

ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer's Disease Pathogenesis.

Ricardo Hernandez Arriaza, Dylan Reil, Nina Fatuzzo, Mengying Fu, Yuqin Dai, David Fernandez Martinez, Hong Jiang, David M Holtzman, Michael D Greicius, Chaitan Khosla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ricardo Hernandez ArriazaDepartment of Chemistry, Stanford University, Stanford, California 94305 United States.
Dylan ReilDepartment of Biochemistry, Stanford University, Stanford, California 94305 United States.
Nina FatuzzoDepartment of Chemistry, Stanford University, Stanford, California 94305 United States.
Mengying FuSarafan ChEM-H, Stanford University, Stanford, California 94305 United States.
Yuqin DaiSarafan ChEM-H, Stanford University, Stanford, California 94305 United States.
David Fernandez MartinezStanford SLAC CryoEM Initiative, Stanford University, Stanford, California 94305 United States.
Hong JiangDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri 63110, United States.
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri 63110, United States.
Michael D GreiciusDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, United States.
Chaitan KhoslaDepartment of Chemistry, Stanford University, Stanford, California 94305 United States.ORCID 0000-0001-6529-495X

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Celeste Marie Karch · 2021 to 2026
$42.0M
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Effect of APOE on CNS Neurons: Role of LRPRF1NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2020 to 2025
$6.5M
Illuminating the APOE Locus with Long-Read Sequencing and Targeted GenomicsR35AG072290 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2021 to 2025
$4.6M
A Modern Flexible Mass Spectrometry Platform for Advancing Proteomics ResearchS10OD030473 · OD · STANFORD UNIVERSITY · PI LEIB, RYAN D. · 2021 to 2021
$1.3M
NCI NIH HHS P30 CA124435NIA NIH HHS P30 AG066515NIA NIH HHS R35 AG072290NIA NIH HHS U19 AG069701NIGMS NIH HHS T32 GM007276NIH HHS S10 OD030473NINDS NIH HHS RF1 NS090934
6 · The paper itself

Abstract

The brain is the most cholesterol-rich organ in the body, and ApoE is the main lipid carrier protein in the brain. Although very little, if any, ApoE exists in its apoprotein form in physiological fluids, recombinant ApoE is typically prepared in a lipid-free state to study its physiological functions. We describe a lipid nanoparticle (LNP) form of ApoE as a primary extracellular product of the eukaryotic protein export system. Whereas the apoprotein is the dominant secreted product when the

Indexed as

Alzheimer DiseaseApolipoproteins ENanoparticlesAnimalsApolipoprotein E3Apolipoprotein E4Cell Line, TumorHumansLiposomesApoE protein, humanApolipoprotein E3Apolipoprotein E4Apolipoproteins ELipid NanoparticlesLiposomes

Identifiers

PMID41134549
PMCPMC12616577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.