ArticleJournal of applied clinical medical physics2025
Comparative evaluation of normal tissue objective functions in robotic radiosurgery planning for solitary brain tumors.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Comparative evaluation of normal tissue objective functions in robotic radiosurgery planning for solitary brain tumors.Journal of applied clinical medical physics · 2025Article
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7 authors.
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Abstract
backgroundThe normal tissue objective (NTO) is an inverse planning approach in radiosurgery, also available for the CyberKnife system. By employing a model function, it aims to achieve precise control over the global dose fall-off in healthy tissue. As a novel technique, NTO can serve as an alternative to the established method, which utilizes layered contours around the target to shape dose gradients and enhance conformity, referred to as Auto-shells in CyberKnife systems. PURPOSE: This study compares the dose distribution achieved with NTO and Auto-shells to evaluate their respective advantages in CyberKnife treatment planning.
methodsA total of 45 patients with brain tumors-including 15 vestibular schwannomas, 15 meningiomas, and 15 metastases, all of whom had previously been treated using an Auto-shells-generated plan, were analyzed. For each case, an alternative NTO-based plan was generated and compared with its Auto-shells counterpart. Key treatment parameters-including nodes, beams, total monitor units (MU), treatment time, new conformity index (nCI), gradient index (GI), and dose exposure volumes to healthy brain tissue (V12Gy and V5Gy)-were evaluated.
resultsBoth methods resulted in comparable plans across many indices. Significant differences were particularly in terms of healthy brain tissue dose exposure. With the NTO method, V12Gy and V5Gy were reduced by up to 14%, and in the case of meningiomas and metastases, the GI was reduced by up to 7%. The conformity, described by the nCI, was within 2%. No significant difference was observed in MU.
conclusionNTO optimization presents a viable option to the Auto-shells method for CyberKnife treatment of brain tumors. By reducing healthy brain tissue exposure without increasing monitor units, it enhances dose-sparing efficiency. However, maintaining optimal conformity remains an important issue, highlighting the trade-offs between precision and tissue preservation.
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