Evidence map›Paper›PMID 41134514›Full record

ReviewAdvances in therapy2025

Visualizing Improvements in Airway Dysfunction After Inhaled Therapy in Patients With Uncontrolled Asthma: A Narrative Review.

Sam Tcherner, Ali Mozaffaripour, Cory Yamashita, Grace Parraga

Abstract readReviewVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sam TchernerRobarts Research Institute, Western University, London, Canada.
Ali MozaffaripourRobarts Research Institute, Western University, London, Canada.
Cory YamashitaDivision of Respirology, Department of Medicine, Western University, London, Canada.
Grace ParragaRobarts Research Institute, Western University, London, Canada. gparraga@uwo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical trials investigating asthma therapies typically rely on pulmonary function tests including spirometry markers, such as forced expiratory volume in 1 s, to evaluate efficacy. While these measures provide insights into the action of bronchodilators on global lung function, their specific effects on the airways and the relationship between clinical improvements and airway dysfunction remains poorly understood. In recent years, pulmonary functional imaging methods, such as hyperpolarized

Indexed as

AsthmaBronchodilator AgentsMagnetic Resonance ImagingPulmonary VentilationXenon IsotopesAdministration, InhalationHumansBronchodilator Agentshyperpolarized Xe-129Xenon Isotopes129Xe magnetic resonance imagingAirway dysfunctionAsthmaFluticasone furoate/umeclidinium/vilanterolICS/LAMA/LABAVentilation defect percent

Identifiers

PMID41134514
PMCPMC12618298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.