Evidence map›Paper›PMID 41134446›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Perilla frutescens Seeds as a Source of Antihypertensive Peptides: Discovery of Novel Tetrapeptides with ACE Inhibitory Activity.

Wei-Ting Hung, Hsien-Yu Liao, Christoper Caesar Yudho Sutopo, Endrika Widyastuti, Tim Chi-Chen Lin, Jue-Liang Hsu

Abstract read
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In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Multitarget Amaranth Peptides: ACE Inhibition, ACE2 Modulation, and Bioavailability Assessment.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei-Ting Hung *Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, Taiwan.
Hsien-Yu Liao *Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, Taiwan.
Christoper Caesar Yudho SutopoDepartment of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.
Endrika WidyastutiDepartment of Food Science and Biotechnology, Faculty of Agricultural Technology, Universitas Brawijaya, Malang, Indonesia.
Tim Chi-Chen LinDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan. chichenlin1@gmail.com.
Jue-Liang HsuDepartment of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, Taiwan. jlhsu@mail.npust.edu.tw.

Funding

National Science and Technology Council NSTC 113-2113-M-020-001
6 · The paper itself

Abstract

Hypertension, a major risk factor for cardiovascular diseases, remains a leading global health concern and has prompted growing interest in angiotensin-converting enzyme (ACE) inhibitory peptides from plant seeds as promising nutraceutical ingredients. To our knowledge, this is the first study to identify antihypertensive peptides from Perilla frutescens seed protein, with thermolysin hydrolysate demonstrated the favorable ACE-inhibitory (ACEI) activity (IC

Indexed as

Angiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsOligopeptidesPerilla frutescensSeedsHumansMolecular Docking SimulationPeptidyl-Dipeptidase APlant ProteinsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsOligopeptidesPeptidyl-Dipeptidase APlant ProteinsACEAntihypertensiveBioactive PeptideCardiovascular DiseaseLC-MS/MSMolecular Docking

Identifiers

PMID41134446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.