SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Does retinal vascular occlusion increase the risk of dementia? A pioneering systematic review and meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can MicroRNAs serve as reliable biomarkers and novel therapeutic targets in age-related macular degeneration? A systematic review and meta-analysis.Journal of translational medicine · 2026Pooled it
- Assessing mortality risk in narcolepsy: Evidence from population studies.PCN reports : psychiatry and clinical neurosciences · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRetinal vascular occlusion (RVO), a common eye condition, has been hypothesized as a potential indicator of neurodegenerative risk. This systematic review and meta-analysis aimed to quantitatively assess the association between RVO and the subsequent development of dementia.
methodsA comprehensive search of major databases was conducted to identify cohort studies investigating the association between RVO and dementia. Data on hazard ratios (HRs) and odds ratios (ORs) for all-cause dementia, Alzheimer's disease, and vascular dementia were extracted. Pooled effect estimates were calculated using a random-effects model.
resultsSix cohort studies with a pooled sample size of 4,638,720 participants were included. The pooled odds ratio for developing dementia in patients with RVO was 1.54 (95% CI (0.95, 2.47), p = 0.08; I² = 62%). The pooled hazard ratio for all-cause dementia was 1.04 (95% CI (0.92, 1.16), p = 0.56; I² = 93%). For Alzheimer's disease, the pooled HR was 1.01 (95% CI (0.91, 1.13), p = 0.83; I² = 78%). Notably, the pooled hazard ratio for vascular dementia showed a statistically significant increased risk in patients with RVO at 1.15 (95% CI (1.04, 1.28), p = 0.008; I² = 40%).
conclusionThis meta-analysis suggests a significant association between RVO and increased vascular dementia risk, highlighting RVO as a potential marker for vascular-related cognitive decline, warranting further investigation.
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Registered trials
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