Evidence map›Paper›PMID 41134395›Full record

ArticleJournal of computer-aided molecular design2025

Identification and biological assessment of amino benzoxazole derivatives as KDR inhibitors and potential anti-cancer agents.

Ali Khudhir, Mahmoud A Al-Sha'er, Mahmoud A Alelaimat, Raed Khashan

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Article in Journal of computer-aided molecular design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ali KhudhirPharmaceutical Science Department, Faculty of Pharmacy, Zarqa University, Zarqa, 13132, Jordan.
Mahmoud A Al-Sha'erPharmaceutical Science Department, Faculty of Pharmacy, Zarqa University, Zarqa, 13132, Jordan. a.mahmoud@zu.edu.jo.
Mahmoud A AlelaimatPharmaceutical Science Department, Faculty of Pharmacy, Zarqa University, Zarqa, 13132, Jordan.
Raed KhashanDivision of Pharmaceutical Sciences, Collage of Pharmacy, Long Island University, Brooklyn, NY, 11201, USA.

Funding

Zarqa University M4-2022
6 · The paper itself

Abstract

A library of 39 amino-benzoxazole derivatives, selected from 57 benzoxazole compounds in the NCI database, was evaluated for their potential as KDR inhibitors using computational docking methods, including CDocker, LibDock, and AutoDock Vina. At a screening concentration of 100 µM, 11 compounds demonstrated over 40% KDR inhibition, with six showing notable activity. The IC50 values of the top six compounds ranged from 6.855 to 50.118 µM, with compound 1 showing the highest inhibitory activity (IC

Indexed as

Antineoplastic AgentsBenzoxazolesProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor-2A549 CellsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansMCF-7 CellsMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsBenzoxazolesKDR protein, humanProtein Kinase InhibitorsVascular Endothelial Growth Factor Receptor-2AminobenzoxazoleAnti-cancer agentsDrug discoveryEGFR1FGFR1KDR inhibitorsStructure–activity relationship (SAR)

Identifiers

PMID41134395

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.