Trial reportLasers in medical science2025
Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Until now, fractional CO2 laser has been the gold standard for photodamage skin treatment. Topical therapy modalities can accelerate the wound healing process and influence the treatment results. However, no standardized topical therapy exists for subjects after fractional CO2 laser procedures. This research aims to determine the efficacy and safety of a cream combination of Stimu-tex AS™ (Spent Grain Wax, Argania Spinosa Kernel Oil, Butyrospermum Parkii (Shea Butter Extract) and Saccharide Isomerate after fractional CO2 laser treatment. A split-face, double-blinded, and randomized study was conducted in 2021 with 20 subjects, each given two types of creams, A and B, following fractional CO2 laser procedure. Subjects will apply cream A and cream B to each side of the face according to the randomization results. One of the creams was a moisturizing combination cream with a combination of Stimu-tex AS™ (Spent Grain Wax, Argania Spinosa Kernel Oil, Butyrospermum Parkii (Shea Butter Extract), and Saccharide Isomerate. Meanwhile, another cream was a placebo. The outcome assessment of this research was carried out subjectively and objectively. The subjective assessment was evaluated using the visual analogue scale (VAS). In contrast, the objective assessment evaluated the degree of erythema using the clinical erythema assessment score (CEA), dermoscopic examination, transepidermal water loss (TEWL) examination with TEWAmeter, and skin capacitance (SCap) with corneometer. This assessment was carried out before the laser procedure, 15 min, on the third day, and
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