Evidence map›Paper›PMID 41134383›Full record

ArticleNeurosurgical review2025

The role of thrombin time as an independent variable in predicting In-Stent stenosis risk after flow diverter treatment for intracranial aneurysms: a retrospective cohort study.

Zhikun Jia, Jiayin Ma, Qile He, Jialin Gao, Qiyu Xie, Zhichao Wu, Jiahe Yin, Mengshi Huang, Zhixi Li, Xin Jin and 7 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhikun JiaNeuroMedical Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, Guangdong, China.
Jiayin MaZhujiang Hospital of Southern Medical University, Guangzhou, 510280, Guangdong, China.
Qile HeZhujiang Hospital of Southern Medical University, Guangzhou, 510280, Guangdong, China.
Jialin GaoZhujiang Hospital of Southern Medical University, Guangzhou, 510280, Guangdong, China.
Qiyu XieZhujiang Hospital of Southern Medical University, Guangzhou, 510280, Guangdong, China.
Zhichao WuZhujiang Hospital of Southern Medical University, Guangzhou, 510280, Guangdong, China.
Jiahe YinDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Mengshi HuangDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Zhixi LiDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Xin JinDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Shenquan GuoDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Wenchao LiuDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Shixing SuDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Fa JinDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Chuanzhi DuanDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China.
Xuying HeNeuroMedical Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, Guangdong, China. 2517079319@qq.com.
Xin ZhangDepartment of Cerebrovascular Surgery, Neurosurgery Center, Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Neurovascular Center of Zhujiang Hospital, The National Key Clinical Specialty, Southern Medical University, Guangzhou, 510280, China. zhangxin19830818@163.com.

Funding

Guangdong Second Provincial Genera Hospital grant WKZX2023CZ0214, grant TJGC-2023012National Natural Science Foundation of China 81974177
6 · The paper itself

Abstract

Unruptured intracranial aneurysms are common neurovascular diseases, and flow diverters (FDs) have emerged as a key treatment modality. However, in-stent stenosis (ISS) remains a frequent complication after FD treatment, increasing the risk of thromboembolic events. Thrombin time (TT), a critical coagulation indicator, has potential associations with ISS risk. The objective of this study was to investigate the relationship between TT and ISS risk, with a focus on potential threshold effects. This multicenter retrospective cohort study included 389 patients with unruptured intracranial aneurysms treated with FD between March 2016 and October 2024. The primary exposure was preoperative TT, and the primary outcome was ISS occurrence during follow-up. Generalized additive models were used to explore non-linear relationships, while segmented linear regression identified threshold points. ISS occurred in 22.62% (88/389) of patients. TT exhibited a non-linear relationship with ISS risk, with a threshold of 19.2 s. For TT values below this threshold, each unit increase was associated with a 59% higher likelihood of developing ISS (OR = 1.59, 95% CI: 1.19-2.13, p = 0.002). These findings may help identify patients at higher risk for ISS who could benefit from more intensive angiographic follow-up with shortened intervals, enabling earlier detection and timely intervention.

Indexed as

Endovascular ProceduresIntracranial AneurysmPostoperative ComplicationsStentsAdultAgedCohort StudiesConstriction, PathologicFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsFlow diverterIntracranial aneurysmStenosisThrombin time

Identifiers

PMID41134383

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