Evidence map›Paper›PMID 41134371›Full record

ArticleCellular and molecular life sciences : CMLS2025

ISG15 modulates inflammatory profiles and ability to activate CD8 + T cells in bone marrow-derived dendritic cells.

Pedro Martínez-Fleta, Clara Pertusa, Irene Fernández-Delgado, Raúl Izquierdo-Serrano, Marta Ramírez-Huesca, Nieves Fernández-Gallego, Diego Calzada-Fraile, Elena Moya-Ruiz, Raquel Castillo-González, Susana Guerra and 2 more

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pedro Martínez-Fleta *Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-6107-0262
Clara Pertusa *Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-6812-653X
Irene Fernández-Delgado *Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-4508-758X
Raúl Izquierdo-SerranoUniversidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-2098-628X
Marta Ramírez-HuescaUniversidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0003-4279-6353
Nieves Fernández-GallegoUniversidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-6968-1444
Diego Calzada-FraileUniversidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-7259-0757
Elena Moya-RuizUniversidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0003-4157-5858
Raquel Castillo-GonzálezUniversidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-9877-2126
Susana GuerraDepartamento de Medicina Preventiva y Salud Pública y Microbiología, Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-9067-2991
Enrique Martín-Gayo *Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-2619-6086
Francisco Sánchez-Madrid *Universidad Autónoma de Madrid, Madrid, Spain. francisco.madrid@uam.es.ORCID http://orcid.org/0000-0001-5303-0762

Funding

NIMHD NIH HHS L60 MD007209
6 · The paper itself

Abstract

The Interferon-Stimulated Gene 15 (ISG15) has a key role during viral infections, since it can modify and regulate the expression of proteins from the host and from viruses. Isg15

Indexed as

Bone Marrow CellsCD8-Positive T-LymphocytesCytokinesDendritic CellsInflammationLymphocyte ActivationUbiquitinsAnimalsCell MovementCell ProliferationCells, CulturedLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutCytokinesG1p2 protein, mouseLipopolysaccharidesUbiquitinsDendritic cellsIL-1βInflammasomeISG15

Identifiers

PMID41134371
PMCPMC12552197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.