Trial reportAbdominal radiology (New York)2026
Percutaneous ultrasound-guided kidney biopsy: a randomized controlled trial comparing longitudinal and cross-sectional probe location cutting techniques.
Trial report in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the efficacy of percutaneous ultrasound-guided renal biopsy using longitudinal and cross-sectional probe location cutting techniques, focusing on the adequacy of tissue sampling and potential complications.
methodsIn this single-center prospective randomized controlled trial (August 2023-January 2024), 70 patients with suspected renal parenchymal disease were randomly assigned to undergo biopsy using either a longitudinal (n = 35) or cross-sectional (n = 35) probe approach. Technical success was defined as obtaining ≥ 10 glomeruli. Outcomes included technical success, glomerular yield, and complications. Subgroup analyses were performed by cortical thickness (< 10 mm) and body mass index (BMI ≥ 30 kg/m²). Multivariate logistic regression was used to identify predictors of success.
resultsTechnical success was achieved in 30/35 patients (85.7%) in the cross-sectional group and 22/35 (62.9%) in the longitudinal group (P = 0.056). Median glomerular yields were similar (20 vs. 18, P = 0.173). Complication rates were low and comparable between groups (1/35 vs. 2/35 required angioembolization). Subgroup analyses suggested higher success rates for the cross-sectional approach in obese patients (100% vs. 50%, P = 0.105) and in those with cortical thickness < 10 mm (80% vs. 42.9%, P = 0.094), though these were not statistically significant. In multivariate analysis, the cross-sectional technique (OR: 7.69; 95% CI: 1.69-50; P = 0.006) and greater cortical thickness (OR: 1.49 per mm; 95% CI: 1.06-2.25; P = 0.019) were independently associated with success.
conclusionThe cross-sectional probe technique was independently associated with higher technical success in renal biopsy without increasing complications. Given the modest sample size and borderline significance in univariate analysis, subgroup findings should be considered exploratory, and larger multicenter trials are warranted for validation.
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