Influence of Nitrative Stress on the Synthesis of Neuromelanin Model Systems.

Silvia De Caro, Fabio Schifano, Enrico Monzani, Stefania Nicolis

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Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Silvia De CaroDepartment of Chemistry, University of Pavia, Via Taramelli 12, Pavia 27100, Italy.

Fabio SchifanoDepartment of Chemistry, University of Pavia, Via Taramelli 12, Pavia 27100, Italy.

Enrico MonzaniDepartment of Chemistry, University of Pavia, Via Taramelli 12, Pavia 27100, Italy.ORCID 0000-0002-8791-6446

Stefania NicolisDepartment of Chemistry, University of Pavia, Via Taramelli 12, Pavia 27100, Italy.ORCID 0000-0002-6618-7555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromelanin is a dark pigment present in the human brain and involved in the onset of Parkinson's disease. Since natural pigment can only be extracted from the human brain in very small quantities, synthetic models of neuromelanin have been developed in recent years for research purposes, consisting of melanin conjugates and proteins made up of dopamine and β-lactoglobulin. Here, we studied the influence of nitrative stress on the synthesis of neuromelanin models, as it is known that reactive nitrogen species are present

Indexed as

MelaninsReactive Nitrogen SpeciesChromatography, High Pressure LiquidDopamineHumansTandem Mass SpectrometryDopamineMelaninsneuromelaninReactive Nitrogen Speciesbiomimetic modelsdopamineneuromelaninParkinson’s diseasereactive nitrogen speciesspectroscopy and spectrometry

Identifiers

PMID41134287

DOI10.1021/acschemneuro.5c00676

PMCPMC12593382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.