ArticleJournal of burn care & research : official publication of the American Burn Association2026
Enhanced Burn Wound Healing and Conversion Prevention Through Inhibition of High Mobility Group Box 1 in a Scald Burn Rat Model.
Article in Journal of burn care & research : official publication of the American Burn Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Immediate post-injury HMGB1 neutralization prevents synaptic dysfunction in burn and hindlimb unloaded rats.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Severe burns trigger hyperinflammatory and hypermetabolic responses, leading to systemic organ damage. High mobility group box 1 (HMGB1) is an inflammatory peptide released from injured sites. This study investigated wound progression in scald burn rats treated with anti-HMGB1 antibody (Ab). Male Sprague-Dawley rats were divided into sham burn (n = 5), burn with vehicle treatment (n = 8), and burn with anti-HMGB1 Ab treatment (n = 8). After 30% total body surface area burns, rats were treated with chicken IgY (burn/vehicle group) or anti-HMGB1 Ab (burn/treatment group). Skin samples were collected at 3 and 14 days after burn for histological analysis of wound composition and healing. ANOVA and post hoc Tukey tests were used for statistical analysis. Anti-HMGB1 Ab improved healing, increasing epithelial thickness on day 14 compared to sham (58 μm ± 22 μm vs 21 μm ± 3 μm; P < .01) and dermal thickness over vehicle (1.7 mm ± 0.23 mm vs 1.4 mm ± 0.25 mm; P < .05). Panniculus carnosus muscle loss was lower in the anti-HMGB1 Ab-treated group than vehicle group (-6.4% ± 1.5% vs -70.9% ± 25%; P = .01). High mobility group box 1 expression decreased in epithelium on day 14 (17.15% ± 11.94% vs 60.83% ± 5.28%; P = .02) and dermal inflammation decreased significantly on day 3 (0.45% ± 0.10% vs 4.05% ± 0.49%; P < .0001). Reducing circulating HMGB1 levels decreases burn wound conversion with improved wound healing.
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