Evidence map›Paper›PMID 41134057›Full record

ArticleJournal of cell science2025

DynAPs and cytoplasmic assembly of axonemal dyneins.

John B Wallingford, Steven L Brody, Amjad Horani, Chanjae Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John B WallingfordDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-8701-4293
Steven L BrodyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
Amjad HoraniDivision of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
Chanjae LeeDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

Funding

Development and function in mucociliary epitheliaR01HL117164 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI John B Wallingford · 2013 to 2026
$4.7M
NRF2 activation program in normal and immotile ciliaR01HL173490 · NHLBI · WASHINGTON UNIVERSITY · PI Amjad Horani · 2024 to 2026
$1.8M
NHLBI NIH HHS R01HL117164NHLBI NIH HHS R01HL12837008NHLBI NIH HHS R01 HL173490NHLBI NIH HHS R01HL173490NHLBI NIH HHS R01HL18075901
6 · The paper itself

Abstract

Motile cilia are microtubule-based organelles that generate fluid flow through coordinated beating, a process powered by axonemal dynein motors. Dyneins are pre-assembled in the cytoplasm by a suite of proteins called dynein axonemal assembly factors (DNAAFs). Genetic variants affecting either the motors or the assembly factors cause motile ciliopathy. In recent years, DNAAFs have been found to function in conjunction with heat-shock protein (HSP) chaperone systems and organize with dynein subunits within cytoplasmic foci known as 'dynein axonemal particles' (DynAPs). In this Perspective, we provide our view on the assembly and potential function of DynAPs, as well as their place within the broader context of motile ciliated cells.

Indexed as

Axonemal DyneinsAxonemeCytoplasmAnimalsCiliaHumansAxonemal DyneinsAxonemal DyneinCiliaDynAPMotile ciliopathy

Identifiers

PMID41134057
PMCPMC13112607

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.