Evidence map›Paper›PMID 41134052›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion.

Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert and 4 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ole Andreas AhlgreenDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Mads Würgler HansenDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Jonas BaakeDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Thomas Engelbrecht HybelDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Rachele RossiDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Xin LaiDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Ishwarya SankaranarayananDepartment of Neuroscience, Center for Advanced Pain Studies, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, 75080, USA.
Johanne Amalie PoldDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Lin LinDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Line ReinertDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Søren Riis PaludanDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Theodore John PriceDepartment of Neuroscience, Center for Advanced Pain Studies, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, 75080, USA.
Lone Tjener PallesenDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.
Christian Bjerggaard VægterDepartment of Biomedicine, Aarhus University, Aarhus, 8000, Denmark.ORCID https://orcid.org/0000-0001-6573-146X

Funding

Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6M
Aarhus University Research Foundation AUFF-E-2022-9-21Aase og Ejnar Danielsens FondDagmar Marshalls FondLundbeck Foundation R313-2019-606Lundbeck Foundation R359-2020-2287NIH HEAL Initiative U19NS130608NINDS NIH HHS U19 NS130608PRECISION Human Pain Network
6 · The paper itself

Abstract

Satellite glial cells (SGCs) enclose sensory neuron somata and initial axon segments in the dorsal root ganglia (DRG) and play a critical role in regulating the neuronal microenvironment. While DRG neuron diversity is well established, SGC heterogeneity remains poorly defined. Here, the first comprehensive in situ characterization of SGC heterogeneity within the mouse DRG is presented. By integrating single-cell RNA sequencing with immunohistochemistry, in situ hybridization, and advanced imaging techniques, four distinct SGC subtypes are identified, validated, and spatially mapped within their native anatomical context: 1) The predominant perisomatic sheaths are defined by marker proteins traditionally used to characterize the entire SGC population, including FABP7, KIR4.1, GS, and CX43. 2) OCT6

Indexed as

Ganglia, SpinalNeurogliaSatellite Cells, PerineuronalAnimalsFemaleMaleMiceMice, Inbred C57BLSensory Receptor Cellsdorsal root ganglionIfit3OCT6satellite glial cellsSCN7ASGC heterogeneity

Identifiers

PMID41134052
PMCPMC12767089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.