ArticleThe International journal of eating disorders2026
Maternal Gestational Low-Grade Inflammation and the Risk of Anorexia Nervosa in Daughters.
Article in The International journal of eating disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Maternal Gestational Low-Grade Inflammation and the Risk of Anorexia Nervosa in Daughters.The International journal of eating disorders · 2026Article
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7 authors.
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Abstract
objectivePrenatal exposures have been suggested to have a programming effect on neural and metabolic development, which may affect the risk of eating disorders. We investigated the association between prospectively measured maternal gestational high-sensitivity C-reactive protein (hs-CRP), an established inflammatory biomarker, and subsequent risk of AN in daughters.
methodThis nested case-control study with sibling-comparison design used systematic sampling from a register-based cohort including all eating disorder patients in Finland born 1991-2000 and diagnosed in specialized health care. Final sample included 150 full triads of females with severe AN (ICD-10 code F50.0), age- and sex-matched population controls, and biological sister controls (total N = 450).
resultsMean gestational hs-CRP values were 4.10 mg/L (SD 5.22), 4.83 mg/L (SD 4.88), and 5.53 mg/L (SD 10.36), for individuals with AN, population controls, and sister controls, respectively. Higher hs-CRP was associated with decreased risk for AN when compared to sister controls (adjusted OR 0.68, 95% Cl 0.48-0.97, p = 0.03). Analyzing hs-CRP in tertiles, maternal hs-CRP in the highest tertile (≥ 5.13 mg/L) versus lowest tertile (≤ 1.94 mg/L) was associated with decreased risk for AN compared to sisters (adjusted OR 0.35, 95% Cl 0.15-0.80, p = 0.01), and to all controls combined (adjusted OR 0.52, 95% Cl 0.29-0.93, p = 0.03). DISCUSSION: We found no evidence that higher gestational CRP would increase the later risk of AN. On the contrary, lower maternal low-grade inflammation early in pregnancy was associated with an increased risk of AN in daughters.
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