Evidence map›Paper›PMID 41133940›Full record

ReviewCell cycle (Georgetown, Tex.)

Advances in DNA damage repair mechanisms in stem cells and their applications.

Dongxu Wei, Yuhao Chang, Yao Yang, Xuanbai Chen, Shiqi Jin, Kainan Huang, Zeyidan Jiapaer, Xianli Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell cycle (Georgetown, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dongxu WeiSchool of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yuhao ChangSchool of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yao YangSchool of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xuanbai ChenSchool of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shiqi JinKing Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi, Arabia.
Kainan HuangCornell University, Ithaca, NY, USA.
Zeyidan JiapaerCollege of Life Science and Technology, Xinjiang University, Urumqi, China.
Xianli WangSchool of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells play a critical role in tissue regeneration and the maintenance of homeostasis. Due to their high replicative potential, stem cells face an elevated risk of DNA damage during DNA replication. Consequently, efficient DNA damage repair (DDR) mechanisms are essential for preserving the genomic stability and functionality of stem cells. This review summarizes the main DNA damage repair mechanisms, examines the characteristics of these DDR pathways in different stem cell types (highlighting their specific features and key molecules), and discusses the clinical significance and applications of stem cell DDR research. Furthermore, we identify current research limitations and propose potential future research directions. Collectively, this review provides a comprehensive perspective on DDR mechanisms in stem cells, laying a foundation for future investigations and potential clinical applications.

Indexed as

DNA DamageDNA RepairStem CellsAnimalsHumansbase excision repaircell-specific DDR-associated molecular regulatorsDNA damageDNA double-strand break repairDNA repairinterstrand cross-link repairmismatch repairnucleotide excision repairStem cellstranslesion DNA synthesis

Identifiers

PMID41133940
PMCPMC12918419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.